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Glyco-Nanoparticles: New Drug Delivery Systems in Cancer Therapy Publisher Pubmed



Khan H1 ; Mirzaei HR2 ; Amiri A3 ; Kupeli Akkol E4 ; Ashhad Halimi SM5 ; Mirzaei H6
Authors
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Authors Affiliations
  1. 1. Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan
  2. 2. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, Ankara, 06330, Turkey
  5. 5. Department of Pharmacy, University of Peshawar, 21200, Pakistan
  6. 6. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Seminars in Cancer Biology Published:2021


Abstract

Cancer is known as one of the most common diseases that are associated with high mobility and mortality in the world. Despite several efforts, current cancer treatment modalities often are highly toxic and lack efficacy and specificity. However, the application of nanotechnology has led to the development of effective nanosized drug delivery systems which are highly selective for tumors and allow a slow release of active anticancer agents. Different Nanoparticles (NPs) such as the silicon-based nano-materials, polymers, liposomes and metal NPs have been designed to deliver anti-cancer drugs to tumor sites. Among different drug delivery systems, carbohydrate-functionalized nanomaterials, specially based on their multi-valent binding capacities and desirable bio-compatibility, have attracted considerable attention as an excellent candidate for controlled release of therapeutic agents. In addition, these carbohydrate functionalized nano-carriers are more compatible with construction of the intracellular delivery platforms like the carbohydrate-modified metal NPs, quantum dots, and magnetic nano-materials. In this review, we discuss recent research in the field of multifunctional glycol-nanoparticles (GNPs) intended for cancer drug delivery applications. © 2019 Elsevier Ltd
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