Cyclic Voltammetric Biosensing of Cellular Ionic Secretion Based on Silicon Nanowires to Detect the Effect of Paclitaxel on Breast Normal and Cancer Cells

Cyclic Voltammetric Biosensing of Cellular Ionic Secretion Based on Silicon Nanowires to Detect the Effect of Paclitaxel on Breast Normal and Cancer Cells Publisher

Shashaani H¹ ; Akbari N¹ ; Faramarzpour M¹ ; Parizi MS¹ ; Vanaei S^{1, 2} ; Khayamian MA¹ ; Faranoush M^{3, 4} ; Anbiaee R⁵ ; Abdolahad M^{1, 6}

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1. Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran
2. School of Biology, College of Science, University of Tehran, P. O. Box 14155-6655, Tehran, Iran
3. Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, P.O. Box: 1996713883, Tehran, Iran
4. Cardio-Oncology Research Center, Rajaie Cardiovascuar Medical & Research Center, Iran University of Medical Sciences, P.O. Box: 1996911151, Tehran, Iran
5. Department of Radiation Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, P.O. Box: 19615-1179, Tehran, Iran
6. Institute of Cancer, Imam Khomeini Hospital Complex, Tehran university of medical sciences, P.O. Box 13145-158, Tehran, Iran

Source: Microelectronic Engineering Published:2021

Abstract

Cell-free analysis based on environmental secretions of the cells/tissues, such as point of care testing, is a rapidly evolving area with advances in integrating sample handling, cheap fabrication, and easy operation. Also, they could be used as complementary cell-based analysis without inducing any perturbation on standard assays. Here, we present a secretion-based cyclic voltammetry biosensor with the assistance of silicon nanowire electrodes to detect ionic concentration changes in the secretions of breast normal and cancer cell lines after being treated by Paclitaxel drug. Changes in CV peaks of the secretions showed a meaningful correlation with the levels of apoptosis after drug treatment in both healthy and malignant cells. Such changes were sharper in MDA-MB-231 than MCF-10A cell lines. This platform could be applied as a cell-free apoptosis sensor to monitor the drug resistance of cancer cells. The sensor is not single used and could be re-used by a simple rinse protocol. © 2021 Elsevier B.V.

2. The Impact of Microelectrode Pattern on the Sensitivity of Tracing Environmental Co2 Deficiency in Cellular Metabolism by a New Design of Electrochemical Biosensor, Biosensors (2023)

3. Label-Free Mechanoelectrical Investigation of Single Cancer Cells by Dielectrophoretic-Induced Stretch Assay, Sensors and Actuators# B: Chemical (2021)

4. Nanobiotechnological Approaches to Overcome Drug Resistance in Breast Cancer, Current Cancer Drug Targets (2015)

Experts (# of related papers)

Alimohammad Alizadeh (1)

Style	Citing Format
MLA	Shashaani H, et al.. "Cyclic Voltammetric Biosensing of Cellular Ionic Secretion Based on Silicon Nanowires to Detect the Effect of Paclitaxel on Breast Normal and Cancer Cells." Microelectronic Engineering, vol. 239-240, no. , 2021, pp. -.
APA	Shashaani H, Akbari N, Faramarzpour M, Parizi MS, Vanaei S, Khayamian MA, Faranoush M, Anbiaee R, Abdolahad M (2021). Cyclic Voltammetric Biosensing of Cellular Ionic Secretion Based on Silicon Nanowires to Detect the Effect of Paclitaxel on Breast Normal and Cancer Cells. Microelectronic Engineering, 239-240(), -.
Chicago	Shashaani H, Akbari N, Faramarzpour M, Parizi MS, Vanaei S, Khayamian MA, Faranoush M, Anbiaee R, Abdolahad M. "Cyclic Voltammetric Biosensing of Cellular Ionic Secretion Based on Silicon Nanowires to Detect the Effect of Paclitaxel on Breast Normal and Cancer Cells." Microelectronic Engineering 239-240, no. (2021): -.
Harvard	Shashaani H et al. (2021) 'Cyclic Voltammetric Biosensing of Cellular Ionic Secretion Based on Silicon Nanowires to Detect the Effect of Paclitaxel on Breast Normal and Cancer Cells', Microelectronic Engineering, 239-240(), pp. -.
Vancouver	Shashaani H, Akbari N, Faramarzpour M, Parizi MS, Vanaei S, Khayamian MA, et al.. Cyclic Voltammetric Biosensing of Cellular Ionic Secretion Based on Silicon Nanowires to Detect the Effect of Paclitaxel on Breast Normal and Cancer Cells. Microelectronic Engineering. 2021;239-240():-.
BibTex	@article{ author = {Shashaani H and Akbari N and Faramarzpour M and Parizi MS and Vanaei S and Khayamian MA and Faranoush M and Anbiaee R and Abdolahad M}, title = {Cyclic Voltammetric Biosensing of Cellular Ionic Secretion Based on Silicon Nanowires to Detect the Effect of Paclitaxel on Breast Normal and Cancer Cells}, journal = {Microelectronic Engineering}, volume = {239-240}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Shashaani H AU - Akbari N AU - Faramarzpour M AU - Parizi MS AU - Vanaei S AU - Khayamian MA AU - Faranoush M AU - Anbiaee R AU - Abdolahad M TI - Cyclic Voltammetric Biosensing of Cellular Ionic Secretion Based on Silicon Nanowires to Detect the Effect of Paclitaxel on Breast Normal and Cancer Cells JO - Microelectronic Engineering VL - 239-240 IS - SP - EP - PY - 2021 ER -

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