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Special Issues Related to The Diagnosis and Management of Acquired Aplastic Anemia in Countries With Restricted Resources, A Report on Behalf of the Eastern Mediterranean Blood and Marrow Transplantation (Embmt) Group and Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation (Saawp of Ebmt) Publisher Pubmed



Iftikhar R1 ; Ahmad P1 ; De Latour R2 ; Dufour C3 ; Risitano A4, 5 ; Chaudhri N6 ; Bazarbachi A7 ; De La Fuente J8 ; Hochsmann B9 ; Osman Ahmed S6 ; Gergis U10 ; Elhaddad A11 ; Halkes C12 ; Albeirouti B13 Show All Authors
Authors
  1. Iftikhar R1
  2. Ahmad P1
  3. De Latour R2
  4. Dufour C3
  5. Risitano A4, 5
  6. Chaudhri N6
  7. Bazarbachi A7
  8. De La Fuente J8
  9. Hochsmann B9
  10. Osman Ahmed S6
  11. Gergis U10
  12. Elhaddad A11
  13. Halkes C12
  14. Albeirouti B13
  15. Alotaibi S14
  16. Kulasekararaj A15
  17. Alzahrani H6
  18. Ben Othman T15, 16
  19. Cesaro S17
  20. Alahmari A6
  21. Rihani R18
  22. Alshemmari S19
  23. Ali Hamidieh A20
  24. Bekadja MA21
  25. Passweg J22
  26. Alkhabori M23
  27. Rasheed W6
  28. Bacigalupo A24
  29. Chaudhry QUN1
  30. Ljungman P25, 26
  31. Marsh J15
  32. El Fakih R6
  33. Aljurf M6
Show Affiliations
Authors Affiliations
  1. 1. Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Pakistan
  2. 2. Saint-Louis Hospital, Paris, France
  3. 3. G Gaslini Children Research Hospital, Genova, Italy
  4. 4. AORN Moscati, Avellino, Italy
  5. 5. Federico II University, Naples, Italy
  6. 6. King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
  7. 7. American University of Beirut Medical Center, Beirut, Lebanon
  8. 8. Imperial College, London, United Kingdom
  9. 9. University Hospital Ulm, Ulm, Germany
  10. 10. Sidney Kimmel Cancer Center, Philadelphia, PA, United States
  11. 11. National Cancer Institute, Cairo University, Cairo, Egypt
  12. 12. Leiden University Medical Centre, Leiden, Netherlands
  13. 13. King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia
  14. 14. Prince Sultan Military Medical City, Riyadh, Saudi Arabia
  15. 15. King’s College Hospital, London, United Kingdom
  16. 16. Center National de Greffe de Moelle Osseuse de Tunis, Tunis, Tunisia
  17. 17. Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
  18. 18. King Hussein Cancer Center, Amman, Jordan
  19. 19. Faculty of Medicine, Kuwait University, Jabriya, Kuwait
  20. 20. Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  21. 21. University Hospital Establishment, Oran, Algeria
  22. 22. University Hospital Basel, Basel, Switzerland
  23. 23. Sultan Qaboos University, Muscat, Oman
  24. 24. Universita’ Cattolica del Sacro Cuore, Roma, Italy
  25. 25. Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden
  26. 26. Division of Hematology Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

Source: Bone Marrow Transplantation Published:2021


Abstract

Aplastic anemia is a relatively rare but potentially fatal disorder, with a reported higher incidence in developing countries in comparison to the West. There are significant variations in epidemiological as well as etiological factors of bone marrow failure syndromes in the developing countries in comparison to the developed world. Furthermore, the management of bone marrow failure syndromes in resource constraint settings has significant challenges including delayed diagnosis and referral, limited accessibility to healthcare facilities, treatment modalities as well as limitations related to patients who require allogeneic stem cell transplantation. Here we will provide a review of the available evidence related to specific issues of aplastic anemia in the developing countries and we summarize suggested recommendations from the Eastern Mediterranean blood and bone marrow transplantation (EMBMT) group and the severe aplastic anemia working party of the European Society of blood and marrow transplantation (SAAWP of EBMT) related to the diagnosis and therapeutic options in countries with restricted resources. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
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