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Assessment of Association Between Hla Alleles and Acquired Aplastic Anemia in Iranian Population Publisher



Taheri M1 ; Akbari MT2 ; Ostadali M3, 4 ; Hamidieh AA5 ; Fallah H6 ; Shadnoush M7 ; Arsangjang S8 ; Ghafourifard S9 ; Sayad A6
Authors
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Authors Affiliations
  1. 1. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Tehran Medical Genetics Laboratory, Tehran, Iran
  3. 3. Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Hematology, Oncology, and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Clinical Nutrition, Faculty of Nutrition & Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Biostatistics and Epidemiology, Cancer Gene Therapy Research Center, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  9. 9. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Ecological Genetics and Genomics Published:2021


Abstract

Aplastic anemia is regarded as an immune-related disorder in which T lymphocytes have a prominent role in destroying bone marrow cells. Previous studies have assessed the role of HLA alleles in development of this disorder. In the current investigation, we genotyped HLA-A/-B/DRB1 alleles in 22 Iranian patients with acquired aplastic anemia and the same number of matched healthy subjects. Frequencies of HLA genotypes were in agreement with the Hardy-Weinberg Equilibrium assumption in aplastic anemia patients and healthy controls. Although some HLA alleles and genotypes were represented with different frequencies between patients and controls, the differences did not reach the level of significance. Thus, we suggest conduction of further studies in larger samples sizes to find whether the observed associations in other populations can be found in Iranian patients as well. © 2020 Elsevier Inc.
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