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Impact of Diabetes Mellitus on Epithelial Ovarian Cancer Survival Publisher Pubmed



Akhavan S1 ; Ghahghaeinezamabadi A1 ; Modaresgilani M1 ; Mousavi AS1 ; Sepidarkish M2 ; Tehranian A3 ; Rezayof E4
Authors
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Authors Affiliations
  1. 1. Gynecology Oncology Department, Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 16635148, Tehran, Iran
  2. 2. Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  3. 3. Department of Obstetrics and Gynecology, Roointan-Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Cancer Published:2018


Abstract

Background: Diabetes mellitus (DM) is associated with poorer outcomes in some cancers. Its effect on ovarian cancer is less clear. We consider the effect of DM on overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). Methods: A retrospective cohort study of 215 patients with EOC diagnosed between 2009 and 2016 was performed. Records were reviewed for standard demographic, pathologic and DM diagnosis data. Cox regression was used to evaluate the relationship between disease status and survival after adjustment for age, body mass index (BMI), parity, stage, grade, histology, debulking status, hypertension (HTN), menopause status and neoadjuant chemotherapy. Results: Patients with DM (27.97, 95%CI: 23.63 to 32.30) had a significantly shorter OS rates compared to patients without DM (41.01, 95%CI: 38.84 to 43.17). The unadjusted hazard ratio (HR) for the association between OS time and DM was 4.76 (95%CI: 2.99 to 7.59, P < 0.001). Following adjustment for demographic and pathologic variables, the HR was 3.93 (95% CI: 2.01 to 7.68; P < 0.001). The PFS in patients with DM (14.10, 95%CI: 11.76 to 16.44) was significantly shorter compared to patients without DM (28.83, 95%CI: 26.13 to 31.54). The unadjusted HR for PFS and DM was 5.69 (95% CI: 3.05 to 10.61; P < 0.001). After adjustment for demographic and pathologic variables, the HR was 2.73 (95% CI, 1.18 to 6.95; P < 0.001). Conclusions: DM can negatively effect on PFS and OS in EOC patients independent of the effect of other variables. © 2018 The Author(s).
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