Resolvin D1 Impacts on Insulin Resistance in Women With Polycystic Ovary Syndrome and Healthy Women

Resolvin D1 Impacts on Insulin Resistance in Women With Polycystic Ovary Syndrome and Healthy Women Publisher Pubmed

Morshedzadeh N¹ ; Saedisomeolia A^{1, 2, 3} ; Djalali M¹ ; Eshraghian MR⁴ ; Hantoushzadeh S⁵ ; Mahmoudi M¹

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1. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pharmacy, School of Medicine, Western Sydney University, NSW, Australia
3. School of Life and Environmental Sciences, Charles Perkins Centre, The University of Sydney, Sydney, Australia
4. Department of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5. Maternal, Fetal and Neonatal Research Center, Vali-Asr Hospital, Imam Khomeini Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran

Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2019

Abstract

Aims: The aim of this study was to determine the association between the intake of omega-3 PUFAs and the serum level of resolvin D1 and insulin resistance in women with Polycystic Ovary Syndrome (PCOS) compared to healthy women. Methods: A cross-sectional study was conducted in 2015–2016 in Tehran, Iran, among females referred to the infertility clinic at Valie-Asr Reproductive Health Research Centre. Thirty-one patients with PCOS (according to the criteria of the European Society for Human Reproduction and Embryology (ESHRE) and the American Society for Reproductive Medicine (ASRM)) and 29 healthy, normal cycling (NC) women of similar age, weight and height were enrolled. Anthropometric measurements, levels of resolvin D1, fasting insulin, glucose levels and insulin resistance index (HOMA) for each of the patients were determined. Results: Intakes of macronutrients (protein, carbohydrates, and total fat) and omega-3 PUFAs were higher in the PCOS group compared to the control group; also, the PCOS group had significantly higher resolvin D1, fasting insulin, glucose levels and HOMA when compared with the control group. Moreover, resolvin D1 correlated negatively with HOMA and fasting insulin levels among both the PCOS and control women. Conclusion: PCOS is associated with insulin resistance. We showed that omega-3 PUFAs can increase the synthesis of resolvin D1. Resolvin D1 is involved in insulin sensitivity by affecting insulin signaling and inflammatory pathways. Therefore, it can be a contributing factor in reducing insulin resistance in PCOS patients. © 2018

Style	Citing Format
MLA	Morshedzadeh N, et al.. "Resolvin D1 Impacts on Insulin Resistance in Women With Polycystic Ovary Syndrome and Healthy Women." Diabetes and Metabolic Syndrome: Clinical Research and Reviews, vol. 13, no. 1, 2019, pp. 660-664.
APA	Morshedzadeh N, Saedisomeolia A, Djalali M, Eshraghian MR, Hantoushzadeh S, Mahmoudi M (2019). Resolvin D1 Impacts on Insulin Resistance in Women With Polycystic Ovary Syndrome and Healthy Women. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13(1), 660-664.
Chicago	Morshedzadeh N, Saedisomeolia A, Djalali M, Eshraghian MR, Hantoushzadeh S, Mahmoudi M. "Resolvin D1 Impacts on Insulin Resistance in Women With Polycystic Ovary Syndrome and Healthy Women." Diabetes and Metabolic Syndrome: Clinical Research and Reviews 13, no. 1 (2019): 660-664.
Harvard	Morshedzadeh N et al. (2019) 'Resolvin D1 Impacts on Insulin Resistance in Women With Polycystic Ovary Syndrome and Healthy Women', Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13(1), pp. 660-664.
Vancouver	Morshedzadeh N, Saedisomeolia A, Djalali M, Eshraghian MR, Hantoushzadeh S, Mahmoudi M. Resolvin D1 Impacts on Insulin Resistance in Women With Polycystic Ovary Syndrome and Healthy Women. Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 2019;13(1):660-664.
BibTex	@article{ author = {Morshedzadeh N and Saedisomeolia A and Djalali M and Eshraghian MR and Hantoushzadeh S and Mahmoudi M}, title = {Resolvin D1 Impacts on Insulin Resistance in Women With Polycystic Ovary Syndrome and Healthy Women}, journal = {Diabetes and Metabolic Syndrome: Clinical Research and Reviews}, volume = {13}, number = {1}, pages = {660-664}, year = {2019} }
RIS	TY - JOUR AU - Morshedzadeh N AU - Saedisomeolia A AU - Djalali M AU - Eshraghian MR AU - Hantoushzadeh S AU - Mahmoudi M TI - Resolvin D1 Impacts on Insulin Resistance in Women With Polycystic Ovary Syndrome and Healthy Women JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews VL - 13 IS - 1 SP - 660 EP - 664 PY - 2019 ER -

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