Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Synbiotic Supplementation on Metabolic Parameters and Apelin in Women With Polycystic Ovary Syndrome: A Randomised Double-Blind Placebo-Controlled Trial Publisher Pubmed



Karimi E1 ; Moini A2, 3 ; Yaseri M4 ; Shirzad N5 ; Sepidarkish M6 ; Hosseinboroujerdi M2 ; Hosseinzadehattar MJ1, 7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, no. 44, Hoj. Street, Naderi Ave. Kesh. Boul., Tehran, 14166-43931, Iran
  2. 2. Department of Gynecology and Obstetrics, Roointan-Arash Maternity Hospital, Tehran University of Medical Sciences, Eastern 162th Street, Baghdarnia Avenue, Resalat Highway, Tehranpars, Tehran, 16539-15981, Iran
  3. 3. Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Eastern 162th Street, Baghdarnia Avenue, Resalat Highway, Tehranpars, Tehran, 16539-15981, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Poorsina Street, Ghods Street, Enghelab Avenue, Tehran, 14176-13151, Iran
  5. 5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Northern Kargar Street, Jalal Al Ahmad Highway, Tehran, 14171-3137, Iran
  6. 6. Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture and Research, no. 24, East. Hafez Alley B.H. Str., Res. High., Tehran, 16635-148, Iran
  7. 7. Iscipline of Medicine, Centre of Research Excellence in Translating Nutritional Science to Good Health, Royal Adelaide Hospital, University of Adelaide, Frome Road, 5000, SA, Australia

Source: British Journal of Nutrition Published:2018


Abstract

Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in women of reproductive age. Insulin resistance is a main pathophysiologic feature in these patients. According to some studies, the intake of probiotic bacteria may improve glucose homoeostasis. The aim of this study was to investigate the effect of synbiotics on metabolic parameters and apelin in PCOS patients. This randomised double-blind placebo-controlled trial was conducted on eighty-eight PCOS women aged 19-37 years old. The participants were randomly assigned to two groups receiving (1) synbiotic supplement (n 44), and (2) placebo (n 44) for 12 weeks. Fasting blood samples were taken at baseline and after 12 weeks. The two groups showed no difference in fasting blood sugar (adjusted mean difference: 0·60; 95 % CI -3·80, 5·00, P=0·727), plasma glucose fasting 2-h (adjusted mean difference 2·09; 95 % CI -9·96, 14·15, P=0·134), HbA1c (adjusted mean difference 0·06; 95 % CI -0·09, 0·22, P=0·959), homoeostatic model assessment-insulin resistance (HOMA-IR) (adjusted mean difference: 0·02; 95 % CI -0·99, 1·03, P=0·837), quantitative insulin sensitivity check index (QUICKI) (adjusted mean difference: -0·02; 95 % CI -0·33, 0·29, P=0·940) and C-reactive protein (CRP) (adjusted mean difference: 0·24; 95 % CI -1·61, 2·08, P=0·141) by the end of the intervention. A significant difference was observed in the mean apelin 36 before and after the intervention between synbiotic and placebo groups (adjusted mean difference: -4·05; 95 % CI -7·15, -0·96, P=0·004). A 12-week synbiotic supplementation has no significant beneficial effects on HOMA-IR and CRP in PCOS patients, whereas the level of apelin 36 significantly decreased. © 2018 The Authors.
Related Docs
View other Related Docs
1. Probiotics As Beneficial Agents in the Management of Diabetes Mellitus: A Systematic Review, Diabetes/Metabolism Research and Reviews (2016)
2. Blood Circulating Levels of Adipokines in Polycystic Ovary Syndrome Patients: A Systematic Review and Meta-Analysis, Reproductive Sciences (2021)
3. The Role of Apelinergic System in Metabolism and Reproductive System in Normal and Pathological Conditions: An Overview, Frontiers in Endocrinology (2023)
4. The Future of Diabetes Management by Healthy Probiotic Microorganisms, Current Diabetes Reviews (2017)
5. Effect of Probiotic and Synbiotic Supplementation on Inflammatory Markers in Health and Disease Status: A Systematic Review and Meta-Analysis of Clinical Trials, Clinical Nutrition (2020)
6. Effect of Probiotic Supplementation on Lipoprotein-Associated Phospholipase A2 in Type 2 Diabetic Patients: A Randomized Double Blind Clinical Controlled Trial, Nutrition and Metabolism (2024)
7. Diabetes Management by Probiotics: Current Knowledge and Future Perspectives, International Journal for Vitamin and Nutrition Research (2016)
8. Plasma Apelin and Asymmetric Dimethylarginine (Adma) Levels Shortly After Laparoscopic Greater Curvature Plication, Obesity Surgery (2017)
Experts (# of related papers)
View all Related Experts
Hanieh-Sadat Ejtahed (7)
Mohammad Javad Hosseinzadeh Attar (4)
Other Related Docs
9. The Effect of Probiotic Supplementation on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes: A Randomized Placebo Controlled Trial, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2019)
10. The Effects of Probiotics or Synbiotics Supplementation in Women With Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Probiotics and Antimicrobial Proteins (2019)
11. Serum C1q and Tumor Necrosis Factor (Tnf)-Related Protein 9 in Women With Polycystic Ovary Syndrome, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2016)
12. Comparative Efficacy and Safety of Probiotics, Prebiotics, and Synbiotics for Type 2 Diabetes Management: A Systematic Review and Network Meta-Analysis, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2024)
13. The Effects of Probiotic Supplementation on Metabolic Status in Type 2 Diabetic Patients With Coronary Heart Disease Irct2017082733941n5 Irct, Diabetology and Metabolic Syndrome (2018)
14. Effects of Synbiotic Supplementation on Serum Adiponectin and Inflammation Status of Overweight and Obese Breast Cancer Survivors: A Randomized, Triple-Blind, Placebo-Controlled Trial, Supportive Care in Cancer (2021)
15. Fermented Foods and Inflammation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Nutrition ESPEN (2020)
16. The Effects of Probiotics, Prebiotics, and Synbiotics on Polycystic Ovarian Syndrome: An Overview of Systematic Reviews, Frontiers in Medicine (2023)
17. Clinical and Metabolic Response to Probiotic Administration in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial, Nutrition (2016)
18. Nutrients and Nutraceuticals in Aging, Nutrients and Nutraceuticals for Active and Healthy Ageing (2020)
19. Daily Consumption of Synbiotic Yogurt Decreases Liver Steatosis in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial, Journal of Nutrition (2018)
20. Association Between Fto Gene Polymorphisms and Type 2 Diabetes Mellitus, Serum Levels of Apelin and Androgen Hormones Among Iranian Obese Women, Gene (2018)
21. Gut Microbiota: A Perspective of Precision Medicine in Endocrine Disorders, Journal of Diabetes and Metabolic Disorders (2020)
22. The Effect of Probiotics on Inflammatory Biomarkers: A Meta-Analysis of Randomized Clinical Trials, European Journal of Nutrition (2020)
23. Assessment of Apelin Serum Levels in Persistent Atrial Fibrillation and Coronary Artery Disease, American Journal of the Medical Sciences (2016)
24. Do Probiotics, Prebiotics and Synbiotics Affect Adiponectin and Leptin in Adults? a Systematic Review and Meta-Analysis of Clinical Trials, Clinical Nutrition (2019)
25. Probiotic Supplementation in Diabetic Hemodialysis Patients Has Beneficial Metabolic Effects, Kidney International (2017)
26. The Effect of Probiotics on Gestational Diabetes and Its Complications in Pregnant Mother and Newborn: A Systematic Review and Meta-Analysis During 2010–2020, Journal of Clinical Laboratory Analysis (2022)
27. Apelin and Stem Cells: The Role Played in the Cardiovascular System and Energy Metabolism, Cell Biology International (2019)
28. The Effects of Probiotic Supplementation on Glycemic Control, Insulin Resistance and Inflammatory Biomarkers of Type 2 Diabetic Patients, Iranian Journal of Endocrinology and Metabolism (2017)
29. The Effect of Probiotic Supplementation on the Risk of Gestational Diabetes Mellitus Among High-Risk Pregnant Women: A Parallel Double-Blind, Randomized, Placebo-Controlled Clinical Trial, Biomedicine and Pharmacotherapy (2021)
30. Effects of Selenium Supplementation on Glucose Homeostasis and Free Androgen Index in Women With Polycystic Ovary Syndrome: A Randomized, Double Blinded, Placebo Controlled Clinical Trial, Journal of Trace Elements in Medicine and Biology (2016)
31. Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovary Syndrome Patients: A Randomized Placebo-Controlled Double-Blind Clinical Trial, Cell Journal (2018)