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Vinylazides: Versatile Synthons and Magical Precursors for the Construction of N-Heterocycles Publisher Pubmed



Tashrifi Z1, 3 ; Mohammadikhanaposhtani M2, 3 ; Larijani B1, 3 ; Hamedifar H2, 3 ; Ansari S2, 3 ; Mahdavi M1, 3
Authors

Source: Molecular Diversity Published:2021


Abstract

Abstract: Nowadays, application of vinylazides as precursors is a key method for the construction of N-heterocycles in organic synthesis. These versatile three-atom synthons can be converted into intermediates such as 2H-azirines, iminyl radicals, iminyl metal complexes, iminyl inions and nitrilium ions that subsequently afford a wide range of polyfunctional cyclic nitrogen-containing compounds. In this review, the reactions of vinylazides leading to these products (in the last decade) are categorized based on the types of the resulting N-heterocyclic rings and a brief and concise description of the reaction mechanisms is presented. Graphic abstract: [Figure not available: see fulltext.]. © 2020, Springer Nature Switzerland AG.
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