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Vinylazides: Versatile Synthons and Magical Precursors for the Construction of N-Heterocycles Publisher Pubmed



Tashrifi Z1, 3 ; Mohammadikhanaposhtani M2, 3 ; Larijani B1, 3 ; Hamedifar H2, 3 ; Ansari S2, 3 ; Mahdavi M1, 3
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. College of Engineering, Faculty of Fouman, University of Tehran, Fouman, Iran
  3. 3. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran

Source: Molecular Diversity Published:2021


Abstract

Abstract: Nowadays, application of vinylazides as precursors is a key method for the construction of N-heterocycles in organic synthesis. These versatile three-atom synthons can be converted into intermediates such as 2H-azirines, iminyl radicals, iminyl metal complexes, iminyl inions and nitrilium ions that subsequently afford a wide range of polyfunctional cyclic nitrogen-containing compounds. In this review, the reactions of vinylazides leading to these products (in the last decade) are categorized based on the types of the resulting N-heterocyclic rings and a brief and concise description of the reaction mechanisms is presented. Graphic abstract: [Figure not available: see fulltext.]. © 2020, Springer Nature Switzerland AG.
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