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The Effect of the Polycystic Ovary Syndrome and Hypothyroidism on the Risk of Fibrocystic Breast Changes: A Meta-Analysis Publisher



Kohnepoushi P1 ; Dehghanbanadaki H2 ; Mohammadzedeh P3 ; Nikouei M1 ; Moradi Y3, 4
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
  2. 2. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  4. 4. Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran

Source: Cancer Cell International Published:2022


Abstract

This meta-analysis aimed to determine the pooled association between polycystic ovary syndrome (PCOS), hypothyroidism, and fibrocystic breast changes. We searched important databases, including PubMed (Medline), Scopus, Web of Science, and Embase to retrieve all relevant studies published from 1990 to April 2021. The bias risk of selected articles was assessed based on the JBI checklist. Our search strategy yielded a total of 487 articles from the international databases. After screening their full-texts, 6 articles met the inclusion criteria and were considered for meta-analysis. The effect of PCOS on the incidence of fibrocystic breast changes was 2.49 (95% CI 1.85–3.34). Also, the effect of hypothyroidism on the incidence of fibrocystic breast changes was 1.90 (95% CI 0.92–3.93). The results showed that women with PCOS were at higher risks to develop fibrocystic breast changes. © 2022, The Author(s).
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