Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Assisted Reproductive Outcomes in Women With Different Polycystic Ovary Syndrome Phenotypes: The Predictive Value of Anti-Mullerian Hormone Publisher Pubmed



Ramezanali F1 ; Ashrafi M1, 2 ; Hemat M1 ; Arabipoor A1 ; Jalali S1 ; Moini A1, 3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  2. 2. Obstetrics and Gynecology Department, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran
  3. 3. Department of Gynecology and Obstetrics, Roointan Arash Women's Health Research and Educational Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Reproductive BioMedicine Online Published:2016


Abstract

This cross-sectional study aimed to evaluate IVF/intracytoplasmic sperm injection (ICSI) outcomes in different polycystic ovary syndrome (PCOS) phenotypes (A, B, C and D) compared with a control group and the predictive values of serum anti-Mullerian hormone (AMH) in PCOS phenotypes for main outcomes. This study evaluated 386 PCOS women and 350 patients with male factor infertility. Women with phenotypes A and C had significantly higher concentrations of AMH than those with phenotype B (P < 0.001). Clinical pregnancy rate (CPR) in the phenotype D group (53.3%) was higher than other groups (32.5%, 26.4% and 36.8%, respectively, in phenotypes A, B and C), but not to a significant level. Multivariable regression analysis, after adjusting for women's age and body mass index, revealed that PCOS phenotypes A and B were associated with a decreased CPR compared with the control group (odds ratio [OR]: 0.46, confidence interval [CI]: 0.26-0.8, P = 0.007 and OR: 0.34, CI: 0.18-0.62, P = 0.001, respectively). It seems a combination of hyperandrogenism and chronic anovulation is associated with a negative impact on the CPR in these patients. These results demonstrated that AMH concentration is related to PCO morphology but not predictive for CPR and live birth rate. © 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Related Docs
1. Analysis of Ovarian Reserve Markers (Amh, Fsh, Afc) in Different Age Strata in Ivf/Icsi Patients, International Journal of Reproductive BioMedicine (2016)
2. The Effect of Weight Loss Program on Serum Anti-Mullerian Hormone Level in Obese and Overweight Infertile Women With Polycystic Ovary Syndrome, Gynecological Endocrinology (2019)
3. High Anti-Mullerian Hormone Strongly Correlates With Reproductive Outcomes in Women Undergoing Assisted Reproduction, Clinical Laboratory (2023)
4. A Randomized Controlled Trial Evaluating the Effect of Ethinyl Estradiol During Clomiphene Citrate Cycles Among Women With Polycystic Ovary Syndrome, International Journal of Gynecology and Obstetrics (2015)
5. The Effect of the Polycystic Ovary Syndrome and Hypothyroidism on the Risk of Fibrocystic Breast Changes: A Meta-Analysis, Cancer Cell International (2022)
6. Comparison of Serum Levels of Amh and Fsh Before and After Unilateral and Bilateral Laparoscopic Ovarian Drilling in Pcos Women Referred to Yas Infertility Clinic, Journal of Obstetrics# Gynecology and Cancer Research (2020)
7. Association Between the Number of Retrieved Mature Oocytes and Insulin Resistance or Sensitivity in Infertile Women With Polycystic Ovary Syndrome, International Journal of Fertility and Sterility (2019)
Experts (# of related papers)
View all Related Experts
Ashraf Moini (3)
Marzieh Aghahosseini (1)