The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial

The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial

Mirzabeigi P¹ ; Mohammadpour AH² ; Salarifar M³ ; Gholami K¹ ; Mojtahedzadeh M¹ ; Javadi MR¹

Show Affiliations

1. Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3. Tehran Heart Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pharmaceutical Research Published:2015

Abstract

Numerous interventional studies in clinical and preclinical setting stated that intake of curcumin may provide protection against cardiovascular disease. The aim of this trial was investigation of curcumin effciency on some cardiovascular risk factors in patients with coronary artery disease (CAD). A total of 33 patients with CAD who fulfilled inclusion and exclusion criteria were entered the study. Patients were randomly assigned to receive curcumin or placebo, 500 mg capsules, four times daily for 8 weeks. Lipid profile, blood glucose and high sensitive C-reactive protein (hs-CRP) levels were analyzed at baseline and two months after treatment. Serum levels of triglycerides (P=0.01), LDL-cholesterol (P=0.03) and VLDL-cholesterol (P=0.04) significantly decreased in the curcumin group compared to baseline, without significant changes in total cholesterol, HDL-cholesterol, blood glucose and hs-CRP levels. In all mentioned laboratory parameters, significant difference was not detected between curcumin and placebo. Although curcumin improved some of lipid profile components, it did not show appreciable effect on infiammatory markers in patients with CAD. Therefore, more detailed assessment of metabolic effects or anti-inflammatory activities of curcumin need to perform by extensive human study. © 2015 by School of Pharmacy

Related Docs

View other Related Docs

1. The Effects of Curcumin Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2019)

2. Longevity and Anti-Aging Effects of Curcumin Supplementation, GeroScience (2024)

3. Beneficial Effects of Nano-Curcumin Supplement on Depression and Anxiety in Diabetic Patients With Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Phytotherapy Research (2020)

4. The Role of Curcumin in Modulating Circular Rnas and Long Non-Coding Rnas in Cancer, Clinical and Translational Oncology (2025)

5. Targeting Mtor With Curcumin: Therapeutic Implications for Complex Diseases, Inflammopharmacology (2025)

6. Pharmacological Activities of Turmerones, Current Medicinal Chemistry (2025)

7. Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders, International Journal of Molecular Sciences (2019)

8. Curcumin in Tissue Engineering: A Traditional Remedy for Modern Medicine, BioFactors (2019)

Experts (# of related papers)

Roja Rahimi (1)

Mohammad Abdollahi (1)

Style	Citing Format
MLA	Mirzabeigi P, et al.. "The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial." Iranian Journal of Pharmaceutical Research, vol. 14, no. 2, 2015, pp. 479-486.
APA	Mirzabeigi P, Mohammadpour AH, Salarifar M, Gholami K, Mojtahedzadeh M, Javadi MR (2015). The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial. Iranian Journal of Pharmaceutical Research, 14(2), 479-486.
Chicago	Mirzabeigi P, Mohammadpour AH, Salarifar M, Gholami K, Mojtahedzadeh M, Javadi MR. "The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial." Iranian Journal of Pharmaceutical Research 14, no. 2 (2015): 479-486.
Harvard	Mirzabeigi P et al. (2015) 'The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial', Iranian Journal of Pharmaceutical Research, 14(2), pp. 479-486.
Vancouver	Mirzabeigi P, Mohammadpour AH, Salarifar M, Gholami K, Mojtahedzadeh M, Javadi MR. The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial. Iranian Journal of Pharmaceutical Research. 2015;14(2):479-486.
BibTex	@article{ author = {Mirzabeigi P and Mohammadpour AH and Salarifar M and Gholami K and Mojtahedzadeh M and Javadi MR}, title = {The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial}, journal = {Iranian Journal of Pharmaceutical Research}, volume = {14}, number = {2}, pages = {479-486}, year = {2015} }
RIS	TY - JOUR AU - Mirzabeigi P AU - Mohammadpour AH AU - Salarifar M AU - Gholami K AU - Mojtahedzadeh M AU - Javadi MR TI - The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial JO - Iranian Journal of Pharmaceutical Research VL - 14 IS - 2 SP - 479 EP - 486 PY - 2015 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract