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Curcumin in Tissue Engineering: A Traditional Remedy for Modern Medicine Publisher Pubmed



Ahangari N1 ; Kargozar S1 ; Ghayourmobarhan M1, 2, 3 ; Baino F4 ; Pasdar A1, 5 ; Sahebkar A6, 7 ; Ferns GAA9 ; Kim HW10, 11, 12 ; Mozafari M13, 14, 15
Authors
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Authors Affiliations
  1. 1. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino, 10129, Italy
  5. 5. Division of Applied Medicine, Medical School, University of Aberdeen, United Kingdom
  6. 6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Brighton and Sussex Medical School, Division of Medical Education, University of Brighton, Rm 342, Mayfield House, Brighton, United Kingdom
  10. 10. Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea
  11. 11. Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan, South Korea
  12. 12. Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Research Center, Dankook University, Cheonan, South Korea
  13. 13. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  14. 14. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  15. 15. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: BioFactors Published:2019


Abstract

Curcumin is the principal polyphenolic compound present in turmeric with broad applications in tissue engineering and regenerative medicine. It has some important inherent properties with the potential to facilitate tissue healing, including anti-inflammatory, anti-oxidant, and antibacterial activities. Therefore, curcumin has been used for the treatment of various damaged tissues, especially wound injuries. There are different forms of curcumin, among which nano-formulations are of a great importance in regenerative medicine. It is also important to design sophisticated delivery systems for controlled/localized delivery of curcumin to the target tissues and organs. Although there are many reports on the advantages of this compound, further research is required to fully explore its clinical usage. The review describes the physicochemical and biological properties of curcumin and the current state of the evidence on its applications in tissue engineering. © 2018 BioFactors, 45(2):135–151, 2019. © 2018 International Union of Biochemistry and Molecular Biology
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