Transition Zone Prostate-Specific Antigen Density Could Better Guide the Rebiopsy Strategy in Men With Prostate Inflammation at Initial Biopsy

Transition Zone Prostate-Specific Antigen Density Could Better Guide the Rebiopsy Strategy in Men With Prostate Inflammation at Initial Biopsy Publisher

Amini E¹ ; Pishgar F¹ ; Ayati M¹ ; Jamshidian H¹ ; Arbab A¹ ; Gooshe M¹ ; Nowroozi MR¹

Show Affiliations

1. Department of Urology, Uro-oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Urology Published:2015

Abstract

Objective To assess the role of transition zone prostate-specific antigen density (TZPSAD) in determining rebiopsy strategy in men with prostate inflammation at initial biopsy. Materials and Methods Analysis was performed on data derived from transrectal ultrasound–guided prostate biopsy registry containing 2461 men who underwent biopsy between March 2005 and January 2015. Eligible patients were divided into 2 groups based on the presence of chronic inflammation in prostate. Group 1 consisted of 920 patients with histopathologic evidence of chronic inflammation and group 2 consisted of 1287 patients with no evidence of inflammation. Receiver operating characteristic curve analysis was performed to evaluate the accuracy of PSA, PSA density (PSAD), and TZPSAD for detecting prostate cancer (PCa) in each group. Patients who underwent rebiopsy during the study period were further assessed to determine factors that may predict the presence of PCa on subsequent biopsies. Results In group 1 patients, at 90% sensitivity for detecting PCa, PSAD and TZPSAD showed 19.7% and 37.8% specificity at cutoff values of 0.10 and 0.27 ng/mL/mL respectively, whereas in group 2 patients, PSAD and TZPSAD revealed 29.8% and 31.4% specificity, respectively. Chronic inflammation at initial biopsy was associated with a significant decrease in the likelihood of cancer detection during rebiopsy (odds ratio, 0.42; 95% confidence interval, 0.18-0.99). TZPSAD was found to be capable of sparing 39.8% of unnecessary rebiopsies in group 1 patients, whereas it spared 20.5% of unnecessary rebiopsies in group 2 patients. Conclusion Applying TZPSAD is advantageous in determining rebiopsy strategy in patients with proven inflammation of prostate at initial biopsy. © 2015 Elsevier Inc.

2. Transition Zone Prostate Specific Antigen Density Improves Prostate Cancer Detection in Iranian Men, Nephro-Urology Monthly (2015)

3. Immunotherapeutic Efficacy of a Lactobacillus Caseilysate As an Adjuvant Combined With a Heated-4T1mammary Carcinoma Cell Lysate in a Murine Model Ofbreast Cancer, Asian Biomedicine (2016)

Experts (# of related papers)

View all Related Experts

Seyed Ali Momeni (1)

Mohammad Reza Nowroozi (1)

Style	Citing Format
MLA	Amini E, et al.. "Transition Zone Prostate-Specific Antigen Density Could Better Guide the Rebiopsy Strategy in Men With Prostate Inflammation at Initial Biopsy." Urology, vol. 86, no. 5, 2015, pp. 985-990.
APA	Amini E, Pishgar F, Ayati M, Jamshidian H, Arbab A, Gooshe M, Nowroozi MR (2015). Transition Zone Prostate-Specific Antigen Density Could Better Guide the Rebiopsy Strategy in Men With Prostate Inflammation at Initial Biopsy. Urology, 86(5), 985-990.
Chicago	Amini E, Pishgar F, Ayati M, Jamshidian H, Arbab A, Gooshe M, Nowroozi MR. "Transition Zone Prostate-Specific Antigen Density Could Better Guide the Rebiopsy Strategy in Men With Prostate Inflammation at Initial Biopsy." Urology 86, no. 5 (2015): 985-990.
Harvard	Amini E et al. (2015) 'Transition Zone Prostate-Specific Antigen Density Could Better Guide the Rebiopsy Strategy in Men With Prostate Inflammation at Initial Biopsy', Urology, 86(5), pp. 985-990.
Vancouver	Amini E, Pishgar F, Ayati M, Jamshidian H, Arbab A, Gooshe M, et al.. Transition Zone Prostate-Specific Antigen Density Could Better Guide the Rebiopsy Strategy in Men With Prostate Inflammation at Initial Biopsy. Urology. 2015;86(5):985-990.
BibTex	@article{ author = {Amini E and Pishgar F and Ayati M and Jamshidian H and Arbab A and Gooshe M and Nowroozi MR}, title = {Transition Zone Prostate-Specific Antigen Density Could Better Guide the Rebiopsy Strategy in Men With Prostate Inflammation at Initial Biopsy}, journal = {Urology}, volume = {86}, number = {5}, pages = {985-990}, year = {2015} }
RIS	TY - JOUR AU - Amini E AU - Pishgar F AU - Ayati M AU - Jamshidian H AU - Arbab A AU - Gooshe M AU - Nowroozi MR TI - Transition Zone Prostate-Specific Antigen Density Could Better Guide the Rebiopsy Strategy in Men With Prostate Inflammation at Initial Biopsy JO - Urology VL - 86 IS - 5 SP - 985 EP - 990 PY - 2015 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract