Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Interaction of Genetic Risk Score (Grs) and Plant-Based Diet on Atherogenic Factors and Body Fat Distribution Indices Among Women With Overweight and Obesity: A Cross-Sectional Study Publisher Pubmed



Mm Hajmir Mahya MEHRI ; A Mirzababaei A ; F Abaj FAEZEH ; Y Aali YASAMAN ; M Samadi MAHSA ; K Mirzaei KHADIJEH
Authors

Source: Scientific Reports Published:2025


Abstract

The association between plant-based diets, obesity, cardiovascular disease (CVD), and genetic predisposition is still not fully understood. This study explored how plant-based diets interact with genetic susceptibility to atherosclerosis and body fat in 377 Iranian women aged 18 to 48 who were overweight or obese. Using a validated 147-item food frequency questionnaire (FFQ), we established three plant-based diet indices: the Plant-Based Diet Index (PDI), the Healthy Plant-Based Diet Index (hPDI), and the Unhealthy Plant-Based Diet Index (uPDI). We calculated a Genetic Risk Score (GRS) based on three body mass index (BMI)-related single nucleotide polymorphisms (SNPs) and analyzed its interaction with the PDI. Results showed that tertile 2 of the PDI had a significant negative interaction with moderate and high-risk alleles on key atherogenic factors, including the atherogenic index of plasma (AIP), triglyceride glucose (TyG), lipid accumulation product (LAP), and visceral adiposity index (VAI) (P < 0.05). A borderline negative interaction between tertile 2 of the hPDI and moderate risk alleles regarding the Body Shape Index (ABSI) was also observed (P = 0.05). Conversely, tertile 2 of the uPDI had a significant positive interaction with moderate risk alleles related to both the Castelli Risk Index I (CRI.I) and II (CRI.II) (P = 0.03). This study suggests that interactions between genetic susceptibility and plant-based diet indices are linked to atherogenic factors and body composition. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. The Mediatory Effect of Inflammatory Markers on the Association Between a Body Shape Index and Body Roundness Index With Cardiometabolic Risk Factor in Overweight and Obese Women: A Cross-Sectional Study, Frontiers in Nutrition (2023)
2. The Association Between Adherence to Diet Quality Index and Cardiometabolic Risk Factors in Overweight and Obese Women: A Cross-Sectional Study, Frontiers in Public Health (2023)
3. Evaluation of Several Anthropometric and Metabolic Indices As Correlates of Hyperglycemia in Overweight/Obese Adults, Diabetes# Metabolic Syndrome and Obesity (2020)
Experts (# of related papers)
View all Related Experts
Leila Azadbakht (7)
Khadijeh Mirzaei (4)
Other Related Docs
4. The Relationship Between Dietary Phytochemical Index and Novel Anthropometric Indices and the Severity of Diabetic Foot Ulcers in Adults With Type 2 Diabetes: A Cross-Sectional Study, BMC Endocrine Disorders (2024)
5. Association of Quality and Quantity of Macronutrients Intake With Obesity, New Anthropometric Indices, Lipid Accumulation, and Blood Lipid Risk Index in Tehranian Women, Food Science and Nutrition (2024)
6. Association Between Lifelines Diet Score (Llds) and Some Novel Anthropometric Indices, Including Body Roundness Index (Bri), a Body Shape Index (Absi), Visceral Adiposity Index (Vai), and Body Adiposity Index (Bai), in Iranian Women: A Cross-Sectional Study, BMC Women's Health (2024)
7. How Is Healthy Eating Index-2015 Related to Risk Factors for Cardiovascular Disease in Patients With Type 2 Diabetes, Frontiers in Nutrition (2023)
8. Effect Modification of General and Central Obesity by Sex and Age on Cardiovascular Outcomes: Targeted Maximum Likelihood Estimation in the Atherosclerosis Risk in Communities Study, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2021)
9. Which Anthropometric and Metabolic Index Is Superior in Hypertension Prediction Among Overweight/Obese Adults?, Integrated Blood Pressure Control (2021)
10. Comparison of Anthro-Metabolic Indicators for Predicting the Risk of Metabolic Syndrome in the Elderly Population: Bushehr Elderly Health (Beh) Program, Journal of Diabetes and Metabolic Disorders (2021)
11. Association Between Plant and Animal Proteins Intake With Lipid Profile and Anthropometric Indices: A Cross-Sectional Study, Nutrition and Health (2024)
12. The Association Between Plant-Based Diet Indices and Metabolic Syndrome in Iranian Older Adults, Nutrition and Health (2021)
13. Estimating the Effects of Body Mass Index and Central Obesity on Stroke in Diabetics and Non-Diabetics Using Targeted Maximum Likelihood Estimation: Atherosclerosis Risk in Communities Study, Obesity Science and Practice (2020)
14. Associations of Plant-Based Dietary Patterns With Cardiovascular Risk Factors in Women, Journal of Cardiovascular and Thoracic Research (2022)
15. The Association Between Food Insecurity and Obesity, a Body Shape Index and Body Roundness Index Among Us Adults, Scientific Reports (2024)
16. The Association Between the Dietary Behavior, Diet Quality, and Lifestyle Scores With Anthropometric Indices and Happiness Levels Among University Students, BMC Nutrition (2024)
17. Circulating Inflammatory Markers May Mediate the Relationship Between Healthy Plant-Based Diet and Metabolic Phenotype Obesity in Women: A Cross-Sectional Study, International journal of clinical practice (2022)
18. The Association Between Recommended and Non-Recommended Food Scores on Cardiovascular Risk Factors in Obese and Overweight Adult Women: A Cross-Sectional Study, BMC Public Health (2022)
19. Comparing the Risk of Cardiovascular Diseases and All-Cause Mortality in Four Lifestyles With a Combination of High/Low Physical Activity and Healthy/Unhealthy Diet: A Prospective Cohort Study, International Journal of Behavioral Nutrition and Physical Activity (2022)
20. Association of Diet Quality and Food Insecurity With Metabolic Syndrome in Obese Adults, International Journal of Preventive Medicine (2021)