Synthesis and Anticancer Activity of N -Substituted 2-Arylquinazolinones Bearing Trans -Stilbene Scaffold

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Synthesis and Anticancer Activity of N -Substituted 2-Arylquinazolinones Bearing Trans -Stilbene Scaffold Publisher Pubmed

Mahdavi M¹ ; Pedrood K² ; Safavi M³ ; Saeedi M^{4, 5} ; Pordeli M⁶ ; Ardestani SK⁶ ; Emami S⁷ ; Adib M² ; Foroumadi A¹ ; Shafiee A¹

Source: European Journal of Medicinal Chemistry Published:2015

Abstract

A novel series of 2-arylquinazolinones 7a-o bearing trans-stilbene moiety were designed, synthesized, and evaluated against human breast cancer cell lines including human breast adenocarcinoma (MCF-7 and MDA-MB-231) and human ductal breast epithelial tumor (T-47D). Among the tested compounds, the sec-butyl derivative 7h showed the best profile of activity (IC50 < 5 μM) against all cell lines, being 2-fold more potent than standard drug, etoposide. Our investigation revealed that the cytotoxic activity was significantly affected by N3-alkyl substituents. Furthermore, the morphological analysis by acridine orange/ethidium bromide double staining test and flow cytometry analysis indicated that the prototype compound 7h can induce apoptosis in MCF-7 and MDA-MB-231 cells. © 2015 Elsevier Masson SAS. © 2015 Elsevier Masson SAS.

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Style	Citing Format
MLA	Mahdavi M, et al.. "Synthesis and Anticancer Activity of N -Substituted 2-Arylquinazolinones Bearing Trans -Stilbene Scaffold." European Journal of Medicinal Chemistry, vol. 95, no. , 2015, pp. 492-499.
APA	Mahdavi M, Pedrood K, Safavi M, Saeedi M, Pordeli M, Ardestani SK, Emami S, Adib M, Foroumadi A, Shafiee A (2015). Synthesis and Anticancer Activity of N -Substituted 2-Arylquinazolinones Bearing Trans -Stilbene Scaffold. European Journal of Medicinal Chemistry, 95(), 492-499.
Chicago	Mahdavi M, Pedrood K, Safavi M, Saeedi M, Pordeli M, Ardestani SK, Emami S, Adib M, Foroumadi A, Shafiee A. "Synthesis and Anticancer Activity of N -Substituted 2-Arylquinazolinones Bearing Trans -Stilbene Scaffold." European Journal of Medicinal Chemistry 95, no. (2015): 492-499.
Harvard	Mahdavi M et al. (2015) 'Synthesis and Anticancer Activity of N -Substituted 2-Arylquinazolinones Bearing Trans -Stilbene Scaffold', European Journal of Medicinal Chemistry, 95(), pp. 492-499.
Vancouver	Mahdavi M, Pedrood K, Safavi M, Saeedi M, Pordeli M, Ardestani SK, et al.. Synthesis and Anticancer Activity of N -Substituted 2-Arylquinazolinones Bearing Trans -Stilbene Scaffold. European Journal of Medicinal Chemistry. 2015;95():492-499.
BibTex	@article{ author = {Mahdavi M and Pedrood K and Safavi M and Saeedi M and Pordeli M and Ardestani SK and Emami S and Adib M and Foroumadi A and Shafiee A}, title = {Synthesis and Anticancer Activity of N -Substituted 2-Arylquinazolinones Bearing Trans -Stilbene Scaffold}, journal = {European Journal of Medicinal Chemistry}, volume = {95}, number = {}, pages = {492-499}, year = {2015} }
RIS	TY - JOUR AU - Mahdavi M AU - Pedrood K AU - Safavi M AU - Saeedi M AU - Pordeli M AU - Ardestani SK AU - Emami S AU - Adib M AU - Foroumadi A AU - Shafiee A TI - Synthesis and Anticancer Activity of N -Substituted 2-Arylquinazolinones Bearing Trans -Stilbene Scaffold JO - European Journal of Medicinal Chemistry VL - 95 IS - SP - 492 EP - 499 PY - 2015 ER -

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