Synthesis and Biological Evaluation of New Coumarins Bearing 2,4-Diaminothiazole-5-Carbonyl Moiety

Synthesis and Biological Evaluation of New Coumarins Bearing 2,4-Diaminothiazole-5-Carbonyl Moiety Publisher Pubmed

Ayati A¹ ; Oghabi Bakhshaiesh T² ; Moghimi S¹ ; Esmaeili R² ; Majidzadeha K² ; Safavi M³ ; Firoozpour L¹ ; Emami S⁴ ; Foroumadi A^{1, 5}

Show Affiliations

1. The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
2. Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
3. Department of Biotechnology, Iranian Research Organization for Science and Technology, P. O. Box 3353-5111, Tehran, Iran
4. Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: European Journal of Medicinal Chemistry Published:2018

Abstract

A series of new coumarin-containing compounds 3a-l and 4a-c was designed and synthesized based on the chalcone-type 4-amino-5-cinnamoylthiazole scaffold 2, and screened for their in vitro anticancer and antioxidant activities. Representatively, the 2-thiomorpholinothiazole derivative 3k with IC50 values of 7.5–16.9 μg/ml demonstrated good cytotoxic effects against tested cell lines MCF-7, HepG2 and SW480. Further investigation by flow cytometric analysis confirmed that this compound induces apoptotic cell death in MCF-7 cells and cause G1-phase arrest in the cell cycle. Moreover, most of compounds had intrinsic potential for radical scavenging activity and ferric-reducing power as investigated by DPPH and FRAP assays. © 2018 Elsevier Masson SAS

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Style	Citing Format
MLA	Ayati A, et al.. "Synthesis and Biological Evaluation of New Coumarins Bearing 2,4-Diaminothiazole-5-Carbonyl Moiety." European Journal of Medicinal Chemistry, vol. 155, no. , 2018, pp. 483-491.
APA	Ayati A, Oghabi Bakhshaiesh T, Moghimi S, Esmaeili R, Majidzadeha K, Safavi M, Firoozpour L, Emami S, Foroumadi A (2018). Synthesis and Biological Evaluation of New Coumarins Bearing 2,4-Diaminothiazole-5-Carbonyl Moiety. European Journal of Medicinal Chemistry, 155(), 483-491.
Chicago	Ayati A, Oghabi Bakhshaiesh T, Moghimi S, Esmaeili R, Majidzadeha K, Safavi M, Firoozpour L, Emami S, Foroumadi A. "Synthesis and Biological Evaluation of New Coumarins Bearing 2,4-Diaminothiazole-5-Carbonyl Moiety." European Journal of Medicinal Chemistry 155, no. (2018): 483-491.
Harvard	Ayati A et al. (2018) 'Synthesis and Biological Evaluation of New Coumarins Bearing 2,4-Diaminothiazole-5-Carbonyl Moiety', European Journal of Medicinal Chemistry, 155(), pp. 483-491.
Vancouver	Ayati A, Oghabi Bakhshaiesh T, Moghimi S, Esmaeili R, Majidzadeha K, Safavi M, et al.. Synthesis and Biological Evaluation of New Coumarins Bearing 2,4-Diaminothiazole-5-Carbonyl Moiety. European Journal of Medicinal Chemistry. 2018;155():483-491.
BibTex	@article{ author = {Ayati A and Oghabi Bakhshaiesh T and Moghimi S and Esmaeili R and Majidzadeha K and Safavi M and Firoozpour L and Emami S and Foroumadi A}, title = {Synthesis and Biological Evaluation of New Coumarins Bearing 2,4-Diaminothiazole-5-Carbonyl Moiety}, journal = {European Journal of Medicinal Chemistry}, volume = {155}, number = {}, pages = {483-491}, year = {2018} }
RIS	TY - JOUR AU - Ayati A AU - Oghabi Bakhshaiesh T AU - Moghimi S AU - Esmaeili R AU - Majidzadeha K AU - Safavi M AU - Firoozpour L AU - Emami S AU - Foroumadi A TI - Synthesis and Biological Evaluation of New Coumarins Bearing 2,4-Diaminothiazole-5-Carbonyl Moiety JO - European Journal of Medicinal Chemistry VL - 155 IS - SP - 483 EP - 491 PY - 2018 ER -

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