Negative Feedback Loop in the Activation of Non-Homologous End Joining Dna Repair Pathway in Helicobacter Pylori Infected Patients With Gastritis

Negative Feedback Loop in the Activation of Non-Homologous End Joining Dna Repair Pathway in Helicobacter Pylori Infected Patients With Gastritis Publisher Pubmed

Amirnorouzi M¹ ; Karimi A² ; Daryani NE³ ; Rajaei A⁴ ; Hashemi M¹ ; Alebouyeh M²

Show Affiliations

1. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2. Pediatric Infections Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Gastroenterology and Hepatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Molecular Biosciences, University of South Florida, Tampa, FL, United States

Source: Scientific Reports Published:2024

Abstract

This study aimed to investigate the activation of error-prone DNA repair pathway in response to Helicobacter pylori infection. Relative changes in the expression levels of genes involved in the non-homologous end-joining pathway (NHEJ) in H. pylori-infected (Cases) and non-infected patients (Controls) with chronic gastritis were measured. A significant increase in the relative expression level of TP53, and significant decrease in the relative transcription of lncRNA LINP1 and XRCC5 were detected in the case group. The transcription of Lig4 and XRCC6 was increased in the case group, which was not statistically significant. The Spearman’s Correlation Coefficient analysis showed a significant positive-correlation between the transcriptional levels of LINP1 and XRCC4/XRCC5/Lig4, and between XRCC5 and TP53/Lig4 both in the case and control groups. Moreover, a significant positive correlation between LinP1 and XRCC6 in the case, and a significant positive correlation between XRCC4 and Lig4, and a negative correlation between TP53 and LinP1/XRCC4/XRCC5 in the control group was detected. Although a relative difference was detected in transcriptional levels of the NHEJ gene mediators, downregulation of LinP1 in H. pylori-infected patients proposed the activation of a negative feedback loop, which may interfere with the NHEJ activity at the early stages of gastritis. © The Author(s) 2024.

2. The Role of Dna Damage Response in Chemo- and Radio-Resistance of Cancer Cells: Can Ddr Inhibitors Sole the Problem?, DNA Repair (2021)

Experts (# of related papers)

Mohammad Ali Mansournia (2)

Style	Citing Format
MLA	Amirnorouzi M, et al.. "Negative Feedback Loop in the Activation of Non-Homologous End Joining Dna Repair Pathway in Helicobacter Pylori Infected Patients With Gastritis." Scientific Reports, vol. 14, no. 1, 2024, pp. -.
APA	Amirnorouzi M, Karimi A, Daryani NE, Rajaei A, Hashemi M, Alebouyeh M (2024). Negative Feedback Loop in the Activation of Non-Homologous End Joining Dna Repair Pathway in Helicobacter Pylori Infected Patients With Gastritis. Scientific Reports, 14(1), -.
Chicago	Amirnorouzi M, Karimi A, Daryani NE, Rajaei A, Hashemi M, Alebouyeh M. "Negative Feedback Loop in the Activation of Non-Homologous End Joining Dna Repair Pathway in Helicobacter Pylori Infected Patients With Gastritis." Scientific Reports 14, no. 1 (2024): -.
Harvard	Amirnorouzi M et al. (2024) 'Negative Feedback Loop in the Activation of Non-Homologous End Joining Dna Repair Pathway in Helicobacter Pylori Infected Patients With Gastritis', Scientific Reports, 14(1), pp. -.
Vancouver	Amirnorouzi M, Karimi A, Daryani NE, Rajaei A, Hashemi M, Alebouyeh M. Negative Feedback Loop in the Activation of Non-Homologous End Joining Dna Repair Pathway in Helicobacter Pylori Infected Patients With Gastritis. Scientific Reports. 2024;14(1):-.
BibTex	@article{ author = {Amirnorouzi M and Karimi A and Daryani NE and Rajaei A and Hashemi M and Alebouyeh M}, title = {Negative Feedback Loop in the Activation of Non-Homologous End Joining Dna Repair Pathway in Helicobacter Pylori Infected Patients With Gastritis}, journal = {Scientific Reports}, volume = {14}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Amirnorouzi M AU - Karimi A AU - Daryani NE AU - Rajaei A AU - Hashemi M AU - Alebouyeh M TI - Negative Feedback Loop in the Activation of Non-Homologous End Joining Dna Repair Pathway in Helicobacter Pylori Infected Patients With Gastritis JO - Scientific Reports VL - 14 IS - 1 SP - EP - PY - 2024 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract