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The Role of Dna Damage Response in Chemo- and Radio-Resistance of Cancer Cells: Can Ddr Inhibitors Sole the Problem? Publisher Pubmed



Sadoughi F1 ; Mirsafaei L2 ; Dana PM1 ; Hallajzadeh J3 ; Asemi Z1 ; Mansournia MA4 ; Montazer M5 ; Hosseinpour M6 ; Yousefi B6, 7
Authors
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Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Cardiology, Ramsar Campus, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Biochemistry and Nutrition, Research Center for Evidence-Based Health Management, Maragheh University of Medical Sciences, Maragheh, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Thorax Surgery, Tuberculosis and Lung Disease Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Source: DNA Repair Published:2021


Abstract

Up to now, many improvements have been made in providing more therapeutic strategies for cancer patients. The lack of susceptibility to common therapies like chemo- and radio-therapy is one of the reasons why we need more methods in the field of cancer therapy. DNA damage response (DDR) is a set of mechanisms which identifies DNA lesions and triggers the repair process for restoring DNA after causing an arrest in the cell cycle. The ability of DDR in maintaining the genome stability and integrity can be favorable to cancerous cells which are exposed to radiation therapy or are treated with chemotherapeutic agents. When DDR mechanisms are error-free in cancer cells, they can escape the expected cellular death and display resistance to treatment. In this regard, targeting different components of DDR can help to increase the susceptibility of advanced tumors to chemo- and radio-therapy. © 2021 Elsevier B.V.
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