Congenital Combined Deficiency of Coagulation Factors: A Study of Seven Patients

Congenital Combined Deficiency of Coagulation Factors: A Study of Seven Patients Publisher Pubmed

Naderi M¹ ; Tabibian S² ; Hosseini MS² ; Alizadeh S² ; Hosseini S³ ; Shamsizadeh M⁴ ; Dorgalaleh A²

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1. Genetic Research Center in Non-Communicable Disease, Zahedan University of Medical Sciences, Iran
2. Department of Hematology, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Hematology, Allied Medical School, Iran University of Medical Sciences, Iran
4. School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran

Source: Blood Coagulation and Fibrinolysis Published:2015

Abstract

Combined deficiency of coagulation factors is considered as an extremely rare bleeding disorder (RBD) inherited in an autosomal recessive pattern. This disorder is more likely to occur in regions with a high rate of consanguineous marriages or in restricted communities. Sistan and Baluchistan, a province in southeast of Iran with a high rate of consanguinity, is a clear model of such regions with a very high prevalence of recessively inherited disorders. The aim of this study was to report the frequency of combined factor deficiency in this province. This descriptive study was conducted on 358 patients with RBD. Demographic information and medical history of each patient were recorded, and the patients were examined by a physician. Routine screening tests were carried out for all patients, and further coagulation tests including coagulation factor activity and antigen assays were subsequently performed for all suspected patients. Among 358 patients, four were found to be affected with combined factor (F)V and FVIII deficiency (F5F8D). In addition, one patient with combined deficiency of FVII-FXIII, one with combined FVII-FX and one with combined FVIII-FIX deficiency were identified. In Sistan and Baluchistan Province, coinheritance of recessively inherited disorders like combined coagulation factor deficiencies was surprisingly higher than expected. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.

Style	Citing Format
MLA	Naderi M, et al.. "Congenital Combined Deficiency of Coagulation Factors: A Study of Seven Patients." Blood Coagulation and Fibrinolysis, vol. 26, no. 1, 2015, pp. 59-62.
APA	Naderi M, Tabibian S, Hosseini MS, Alizadeh S, Hosseini S, Shamsizadeh M, Dorgalaleh A (2015). Congenital Combined Deficiency of Coagulation Factors: A Study of Seven Patients. Blood Coagulation and Fibrinolysis, 26(1), 59-62.
Chicago	Naderi M, Tabibian S, Hosseini MS, Alizadeh S, Hosseini S, Shamsizadeh M, Dorgalaleh A. "Congenital Combined Deficiency of Coagulation Factors: A Study of Seven Patients." Blood Coagulation and Fibrinolysis 26, no. 1 (2015): 59-62.
Harvard	Naderi M et al. (2015) 'Congenital Combined Deficiency of Coagulation Factors: A Study of Seven Patients', Blood Coagulation and Fibrinolysis, 26(1), pp. 59-62.
Vancouver	Naderi M, Tabibian S, Hosseini MS, Alizadeh S, Hosseini S, Shamsizadeh M, et al.. Congenital Combined Deficiency of Coagulation Factors: A Study of Seven Patients. Blood Coagulation and Fibrinolysis. 2015;26(1):59-62.
BibTex	@article{ author = {Naderi M and Tabibian S and Hosseini MS and Alizadeh S and Hosseini S and Shamsizadeh M and Dorgalaleh A}, title = {Congenital Combined Deficiency of Coagulation Factors: A Study of Seven Patients}, journal = {Blood Coagulation and Fibrinolysis}, volume = {26}, number = {1}, pages = {59-62}, year = {2015} }
RIS	TY - JOUR AU - Naderi M AU - Tabibian S AU - Hosseini MS AU - Alizadeh S AU - Hosseini S AU - Shamsizadeh M AU - Dorgalaleh A TI - Congenital Combined Deficiency of Coagulation Factors: A Study of Seven Patients JO - Blood Coagulation and Fibrinolysis VL - 26 IS - 1 SP - 59 EP - 62 PY - 2015 ER -

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