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Cerebral Venous Thrombosis, Neutropenia and Iron-Deficiency Anemia in Huntington Disease Publisher Pubmed



Tabibian F1 ; Adibi I2 ; Ardestani PE2 ; Tabibian E3 ; Akbaripour S4 ; Burk K5
Authors
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Authors Affiliations
  1. 1. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Radiology, Medical Imaging Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Ayatollah Kashani Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Kliniken Schmieder Stuttgart-Gerlingen, Gerlingen, Germany

Source: Neurodegenerative Disease Management Published:2021


Abstract

Neurologic and nonneurologic manifestations have been shown for Huntington disease (HD) as a genetic neurodegenerative disorder. However, cerebral venous thrombosis (CVT), iron-deficiency anemia and neutropenia have not been reported as its presentations to date. We introduce the first case of a HD patient with CVT, iron-deficiency anemia and neutropenia. All transient and chronic risk factors for development of these manifestations were ruled out. According to the experimental evidences reviewed in this article, we suggest that HD itself could promote formation of CVT, iron-deficiency anemia and neutropenia through vascular and blood cell abnormalities. © 2021 Future Medicine Ltd.