Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients

Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients Publisher

Yazarlou F¹ ; Afsharpad M² ; Oskooei VK³ ; Nekoohesh L⁴ ; Moharrami T⁵ ; Samadaian N¹ ; Ghafourifard S³ ; Modarressi MH^{1, 6}

Show Affiliations

1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Cancer Control Research Center, Cancer Control Foundation, Iran University of Medical Sciences, Tehran, Iran
3. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, International Campus, Tehran, Iran
5. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, International Campus, Tehran, Iran
6. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran

Source: Meta Gene Published:2018

Abstract

Background: Bladder cancer (BC) is a frequent cancer with high morbidity and mortality. Method: We assessed expression of NMP22, BAG3, BCL2 and BAX in BC samples, adjacent non-neoplastic tissues (ANNTs), urinary cell pellets (UCP) of the same patients and non-malignant conditions (NM). Results: NMP22 was up-regulated in tumoral tissues compared with ANNTs and in UCP of BC patients compared with UCP of NM. BCL2 and BAX were down-regulated in BC tissues compared with ANNTs. BAG3 and BAX were down-regulated in UCP of BC compared with NM. The combination of all four genes had 100% sensitivity and specificity for detection of BC in urine. Conclusion: Expression analysis of these genes in tumor or urine is a tool for detection of BC. © 2018

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Experts (# of related papers)

Mohammad Hossein Modarressi (2)

Elahe Motevaseli (1)

Style	Citing Format
MLA	Yazarlou F, et al.. "Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients." Meta Gene, vol. 18, no. , 2018, pp. 137-142.
APA	Yazarlou F, Afsharpad M, Oskooei VK, Nekoohesh L, Moharrami T, Samadaian N, Ghafourifard S, Modarressi MH (2018). Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients. Meta Gene, 18(), 137-142.
Chicago	Yazarlou F, Afsharpad M, Oskooei VK, Nekoohesh L, Moharrami T, Samadaian N, Ghafourifard S, Modarressi MH. "Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients." Meta Gene 18, no. (2018): 137-142.
Harvard	Yazarlou F et al. (2018) 'Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients', Meta Gene, 18(), pp. 137-142.
Vancouver	Yazarlou F, Afsharpad M, Oskooei VK, Nekoohesh L, Moharrami T, Samadaian N, et al.. Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients. Meta Gene. 2018;18():137-142.
BibTex	@article{ author = {Yazarlou F and Afsharpad M and Oskooei VK and Nekoohesh L and Moharrami T and Samadaian N and Ghafourifard S and Modarressi MH}, title = {Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients}, journal = {Meta Gene}, volume = {18}, number = {}, pages = {137-142}, year = {2018} }
RIS	TY - JOUR AU - Yazarlou F AU - Afsharpad M AU - Oskooei VK AU - Nekoohesh L AU - Moharrami T AU - Samadaian N AU - Ghafourifard S AU - Modarressi MH TI - Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients JO - Meta Gene VL - 18 IS - SP - 137 EP - 142 PY - 2018 ER -

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