Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Expression Analysis of a Panel of Cancer-Testis Antigens in Bladder Cancer Publisher Pubmed



Yazarlou F1 ; Kholghioskooei V2 ; Afsharpad M3 ; Nekoohesh L4 ; Moharrami T5 ; Rad HM6 ; Ghafourifard S2, 7 ; Modarressi MH1, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
  2. 2. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran
  3. 3. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
  4. 4. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, International Campus, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
  5. 5. Department of Medical Genetics, School of Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Molecular Genetics, Faculty of Biological Science, Tarbiat Modares University, Tehran, 1411713114, Iran
  7. 7. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran

Source: Personalized Medicine Published:2018


Abstract

Aim: Cancer-testis antigens (CTAs) have specific expression in gametogenic tissues and aberrant expression in cancers. Materials & methods: We assessed expression of five testis-specific genes namely KIF2B, CST8, TMEM225, RBM46, OAZ3 in bladder cancer tissues, adjacent non-neoplastic tissues and urinary cell pellets (UCPs) of bladder cancer patients compared with nonmalignant conditions.Results: Expressions of all CTAs were higher in UCPs of bladder cancer patients compared with nonmalignant conditions. RBM46 expression in UCPs was higher in patients with recurrent tumors compared with primary tumors and in patients without hematuria compared with those having hematuria. TMEM225 expression in tumoral tissues was higher in high-grade tumors compared with low-grade tumors. Conclusion: Expression analysis of CTAs in UCP might provide diagnostic information about bladder cancer. © 2018 Future Medicine Ltd.
Related Docs
1. Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients, Meta Gene (2018)
2. Urine Exosome Gene Expression of Cancer-Testis Antigens for Prediction of Bladder Carcinoma, Cancer Management and Research (2018)
3. An Introduction to Expression and Regulation of Testicular Cancer Antigens: Review Article, Tehran University Medical Journal (2018)
4. Testicular Mirnas in Relation to Spermatogenesis, Spermatogonial Stem Cells and Cancer/Testis Genes, Scientific African (2019)
5. Plac1: Biology and Potential Application in Cancer Immunotherapy, Cancer Immunology# Immunotherapy (2019)
6. Cancer/Testis Antigens: Expression, Regulation, Tumor Invasion, and Use in Immunotherapy of Cancers, Immunological Investigations (2016)
Experts (# of related papers)
View all Related Experts
Mohammad Hossein Modarressi (2)
Nima Rezaei (1)