Optic Nerve Head Vessel Density in Different Stages of Pseudoexfoliation Disease

Optic Nerve Head Vessel Density in Different Stages of Pseudoexfoliation Disease Publisher Pubmed

Safizadeh M¹ ; Shaabani A¹ ; Kamalipour A² ; Fard MA¹ ; Yeh K² ; Yaseri M¹ ; Hamzeh N¹ ; Khatibi N¹ ; Rao HL³ ; Weinreb R² ; Moghimi S²

Show Affiliations

1. Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Viterbi Family Department of Ophthalmology, Shiley Eye Institute, University of California, University of California at San Diego, Department of Ophthalmology, The Shiley Eye Institute, La Jolla, CA, United States
3. Glaucoma, Narayana Nethralaya, Bangalore, India

Source: British Journal of Ophthalmology Published:2022

Abstract

Purpose To evaluate the superficial vascular density of the optic nerve head in different stages of pseudoexfoliation disease using optical coherence tomography angiography (OCTA). Methods In this cross-sectional study, 57 normal eyes, 41 eyes with pseudoexfoliation syndrome (PXS), 82 eyes with pseudoexfoliation glaucoma (PXG) and 27 non-glaucomatous fellow eyes of PXG (NL-PXG) that had OCTA were included. Circumpapillary RNFL (cpRNFL) thickness and circumpapillary capillary density (cpCD) were compared among the groups after adjusting for confounders using linear-mixed model. Results PXG eyes had thinner global RNFL and lower cpCD (74.2±14.3 μm and 36.7±10.0%) than control (103.3±8.6 μm and 52.5±2.3%), PXS (96.8±8.8 μm and 51.5±2.3%), and NL-PXG eyes (96.3±11.1 μm and 50.1±3.9%) (p<0.001). After adjustment for age, gender and signal strength index, global cpRNFL thickness was comparable among control, PXS and NL-PXG. NL-PXG had the lowest cpCD (p=0.045) and sectoral cpCD compared to PXS and control eyes. Although cpCD was comparable between control and PXS (p=0.425) eyes, sectoral differences (p=0.009 and 0.004, for inferonasal and temporal-inferior cpCD, respectively) were detectable between the two groups. AUROC for differentiating NL-PXG eyes from normal were better for cpCD (0.78) compared to cpRNLF (0.69). Conclusions OCTA can detect reduced capillary density before significant changes in cpRNFL in fellow eyes of PXG patients. This can enable earlier detection of glaucomatous loss in pseudoexfoliation disease and enhance management of the disease. © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

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Style	Citing Format
MLA	Safizadeh M, et al.. "Optic Nerve Head Vessel Density in Different Stages of Pseudoexfoliation Disease." British Journal of Ophthalmology, vol. 106, no. 2, 2022, pp. 223-228.
APA	Safizadeh M, Shaabani A, Kamalipour A, Fard MA, Yeh K, Yaseri M, Hamzeh N, Khatibi N, Rao HL, Weinreb R, Moghimi S (2022). Optic Nerve Head Vessel Density in Different Stages of Pseudoexfoliation Disease. British Journal of Ophthalmology, 106(2), 223-228.
Chicago	Safizadeh M, Shaabani A, Kamalipour A, Fard MA, Yeh K, Yaseri M, Hamzeh N, et al.. "Optic Nerve Head Vessel Density in Different Stages of Pseudoexfoliation Disease." British Journal of Ophthalmology 106, no. 2 (2022): 223-228.
Harvard	Safizadeh M et al. (2022) 'Optic Nerve Head Vessel Density in Different Stages of Pseudoexfoliation Disease', British Journal of Ophthalmology, 106(2), pp. 223-228.
Vancouver	Safizadeh M, Shaabani A, Kamalipour A, Fard MA, Yeh K, Yaseri M, et al.. Optic Nerve Head Vessel Density in Different Stages of Pseudoexfoliation Disease. British Journal of Ophthalmology. 2022;106(2):223-228.
BibTex	@article{ author = {Safizadeh M and Shaabani A and Kamalipour A and Fard MA and Yeh K and Yaseri M and Hamzeh N and Khatibi N and Rao HL and Weinreb R and Moghimi S}, title = {Optic Nerve Head Vessel Density in Different Stages of Pseudoexfoliation Disease}, journal = {British Journal of Ophthalmology}, volume = {106}, number = {2}, pages = {223-228}, year = {2022} }
RIS	TY - JOUR AU - Safizadeh M AU - Shaabani A AU - Kamalipour A AU - Fard MA AU - Yeh K AU - Yaseri M AU - Hamzeh N AU - Khatibi N AU - Rao HL AU - Weinreb R AU - Moghimi S TI - Optic Nerve Head Vessel Density in Different Stages of Pseudoexfoliation Disease JO - British Journal of Ophthalmology VL - 106 IS - 2 SP - 223 EP - 228 PY - 2022 ER -

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