Peripapillary Perfused Capillary Density in Exfoliation Syndrome and Exfoliation Glaucoma Versus Poag and Healthy Controls: An Octa Study

Peripapillary Perfused Capillary Density in Exfoliation Syndrome and Exfoliation Glaucoma Versus Poag and Healthy Controls: An Octa Study Publisher Pubmed

Suwan Y^{1, 2} ; Geyman LS^{1, 3} ; Fard MA⁴ ; Tantraworasin A⁵ ; Chui TY¹ ; Rosen RB¹ ; Ritch R¹

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1. Eihorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States
2. Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
3. Icahn School Medicine at Mount Sinai, New York, NY, United States
4. Farabi Eye Hospital, Tehran, Iran
5. Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

Source: Asia-Pacific Journal of Ophthalmology Published:2018

Abstract

Purpose: To compare the peripapillary perfused capillary density (PCD) among eyes with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), primary open-angle glaucoma (POAG), and controls. Design: Observational, cross-sectional study. Methods: Optical coherence tomography angiography (OCTA) images (4.5 × 4.5 mm) of the optic nerve head were obtained using a commercial spectral domain OCTA system (AngioVue Avanti RTVue-XR, OptoVue, Fremont, CA). Two concentric circles with 1.95-mm (inner) and 3.45-mm (outer) diameters were placed manually, producing an annulus of width 0.75 mm centered at the optic disc. PCD was calculated as the ratio of pixels associated with capillaries to the pixels in the annulus after large blood vessel removal. Continuous variables were assessed by analysis of variance and Tukey honest significant difference (HSD) test. Multiple linear regression analysis was performed to adjust for confounding factors. Results: Forty-three XFG eyes, 31 POAG eyes matched for visual field mean deviation, 33 XFS eyes, and 45 control eyes were analyzed. PCD demonstrated a progressive decrease from controls to XFS to POAG to XFG. Pairwise comparisons revealed significant differences in PCD between each pair of groups (all P < 0.01) except for PCD between XFS and POAG (P = 0.08). A multivariable model adjusting for age and stage showed a more significant decrease in PCD in XFG compared with POAG (P = 0.001). Conclusions: PCD was more significantly decreased in XFG compared with POAG eyes and in XFS compared with control eyes. OCTA provides the first quantitative evidence of the microvascular disturbance that accompanies XFS. Copyright © 2017 Asia-Pacific Academy of Ophthalmology. Unauthorized reproduction of this article is prohibited.

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Style	Citing Format
MLA	Suwan Y, et al.. "Peripapillary Perfused Capillary Density in Exfoliation Syndrome and Exfoliation Glaucoma Versus Poag and Healthy Controls: An Octa Study." Asia-Pacific Journal of Ophthalmology, vol. 7, no. 2, 2018, pp. 84-89.
APA	Suwan Y, Geyman LS, Fard MA, Tantraworasin A, Chui TY, Rosen RB, Ritch R (2018). Peripapillary Perfused Capillary Density in Exfoliation Syndrome and Exfoliation Glaucoma Versus Poag and Healthy Controls: An Octa Study. Asia-Pacific Journal of Ophthalmology, 7(2), 84-89.
Chicago	Suwan Y, Geyman LS, Fard MA, Tantraworasin A, Chui TY, Rosen RB, Ritch R. "Peripapillary Perfused Capillary Density in Exfoliation Syndrome and Exfoliation Glaucoma Versus Poag and Healthy Controls: An Octa Study." Asia-Pacific Journal of Ophthalmology 7, no. 2 (2018): 84-89.
Harvard	Suwan Y et al. (2018) 'Peripapillary Perfused Capillary Density in Exfoliation Syndrome and Exfoliation Glaucoma Versus Poag and Healthy Controls: An Octa Study', Asia-Pacific Journal of Ophthalmology, 7(2), pp. 84-89.
Vancouver	Suwan Y, Geyman LS, Fard MA, Tantraworasin A, Chui TY, Rosen RB, et al.. Peripapillary Perfused Capillary Density in Exfoliation Syndrome and Exfoliation Glaucoma Versus Poag and Healthy Controls: An Octa Study. Asia-Pacific Journal of Ophthalmology. 2018;7(2):84-89.
BibTex	@article{ author = {Suwan Y and Geyman LS and Fard MA and Tantraworasin A and Chui TY and Rosen RB and Ritch R}, title = {Peripapillary Perfused Capillary Density in Exfoliation Syndrome and Exfoliation Glaucoma Versus Poag and Healthy Controls: An Octa Study}, journal = {Asia-Pacific Journal of Ophthalmology}, volume = {7}, number = {2}, pages = {84-89}, year = {2018} }
RIS	TY - JOUR AU - Suwan Y AU - Geyman LS AU - Fard MA AU - Tantraworasin A AU - Chui TY AU - Rosen RB AU - Ritch R TI - Peripapillary Perfused Capillary Density in Exfoliation Syndrome and Exfoliation Glaucoma Versus Poag and Healthy Controls: An Octa Study JO - Asia-Pacific Journal of Ophthalmology VL - 7 IS - 2 SP - 84 EP - 89 PY - 2018 ER -

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