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Sbf2-As1 and Trerna: Novel Lncrna Players in Triple-Negative Breast Cancer Pathogenesis Publisher Pubmed



Kamaliyan Z1 ; Dorraji K2 ; Kakavand S2 ; Azizitabesh G1, 3 ; Mirfakhraie N4 ; Omranipour R5, 6 ; Ahmadinejad N7 ; Yassaee VR1, 3 ; Mirfakhraie R1, 8
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Koodakyar St, Velenjak Ave, Chamran Highway, Tehran, 19395-4719, Iran
  2. 2. Department of Biology, Faculty of Biological Sciences, Tehran North Branch, Islamic Azad University, Tehran, Iran
  3. 3. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of computer engineering, Tehran North Branch, Islamic Azad University, Tehran, Iran
  5. 5. Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Medical imaging center, Cancer Research Institute, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Molecular Biology Reports Published:2023


Abstract

Background: Compared to other breast cancer subtypes, triple-negative breast cancer (TNBC) has always been challenging for clinicians due to its aggressive behavior and lack of a specific treatment. There is a confirmed association between invasive features of tumors and increased epithelial-mesenchymal transition (EMT) process, which is consistent with a higher rate of EMT in TNBC. Methods and results: We investigated the expression of EMT-related genes, SNAI1 and MMP7, and EMT-related lncRNAs, treRNA and SBF2-AS1, in 50 TNBC tumors and 50 non-TNBC tumors to reveal more regulators and effectors involved in TNBC malignancy. In the present study, we showed the overexpression of all the studied genes and lncRNAs in TNBC tumors compared to non-TNBC samples. Moreover, a significant association was observed between MMP7 and treRNA expression levels and larger tumor size. A positive correlation between SNAI1 and lncRNA treRNA expression levels was also detected. Conclusions: Due to the differential expression and the potential diagnostic power of the studied genes, SBF2-AS1 and treRNA can be proposed as new probable biomarkers and therapeutic targets in TNBC. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.
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