Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Potential Roles of Lncrnas Duxap8, Linc00963, and Foxd2-As1 in Luminal Breast Cancer Based on Expression Analysis and Bioinformatic Approaches Publisher Pubmed



Arabpour M1 ; Layeghi SM1 ; Bazzaz JT1 ; Naghizadeh MM2 ; Majidzadeha K3 ; Shakoori A4, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  4. 4. Medical Genetic Ward, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran

Source: Human Cell Published:2021


Abstract

Numerous studies have demonstrated that lncRNAs participate in regulatory networks of different cancers. Dysregulation of various lncRNAs such as DUXAP8, LINC00963, and FOXD2-AS1 has been reported in the development of various cancers. The aim of this study was investigation of the importance and potential roles of DUXAP8, LINC00963, and FOXD2-AS1 in ER+ breast cancer (BC). We examined the expression levels of DUXAP8, LINC00963, and FOXD2-AS1 in 71 luminal A and B tumor tissues and two luminal A cell lines (MCF7 and T47D) compared with adjacent non-tumor tissues and MCF10A cell line by qRT-PCR assay, respectively. For identifying the relation between three lncRNAs and luminal BC, bioinformatic analyses were performed using some databases and software including GENEVESTIGATOR software, GEPIA2, DAVID, REVIGO, STRING, lncATLAS, Kaplan–Meier plotter, starBase, and miRNet tool. The results showed the significant upregulation of all three lncRNAs in luminal A and B tumor specimens and cell lines. Upregulation of DUXAP8 and FOXD2-AS1 was significantly associated with progesterone receptor-positive (PR+) and p53 protein expression in luminal BC patients, respectively. Based on bioinformatic analyses, DUXAP8 can be considered as a prognostic biomarker for patients with luminal BC. DUXAP8, LINC00963, and FOXD2-AS1 are involved in several cancer-associated signaling pathways and multiple cancer-related processes. In addition, bioinformatic analyses indicated that LINC00963/hsa-mir-130a-3p/HSPA8 axis might have potential regulatory role in BC. In conclusion, dysregulation of DUXAP8, LINC00963, and FOXD2-AS1 can play roles in the development of luminal BC. They may exert their functions through involvement in some cancer signaling pathways and processes. In addition, they may interact with miRNAs like predicted interaction of LINC00963 with miR-130a-3p. © 2021, Japan Human Cell Society.
Related Docs
View other Related Docs
1. An Insight Into the Potential Role of Linc00968 in Luminal Breast Cancer: Case-Control Study and Bioinformatics Analysis, Biochemistry and Biophysics Reports (2023)
2. Expression Profiles and Functional Prediction of Long Non-Coding Rnas Linc01133, Zeb1-As1 and Abhd11-As1 in the Luminal Subtype of Breast Cancer, Journal of Translational Medicine (2021)
3. Evaluation of the Potential Role of Long Non-Coding Rna Linc00961 in Luminal Breast Cancer: A Case-Control and Systems Biology Study, Cancer Cell International (2020)
4. Expression Analysis of Wnt Signaling Pathway Related Lncrnas in Periodontitis: A Pilot Case-Control Study, Human Gene (2022)
5. Emt Related Lncrnas' As Novel Biomarkers in Glioblastoma: A Review Article, Tehran University Medical Journal (2021)
6. Non-Coding Rnas and Glioblastoma: Insight Into Their Roles in Metastasis, Molecular Therapy Oncolytics (2022)
7. In Silico Dissection of Mirna Targetome Polymorphisms and Their Role in Regulating Mirna-Mediated Gene Expression in Esophageal Cancer, Cell Biochemistry and Biophysics (2016)
8. Bcl11a and the Correlated Key Genes Ascribable to Globin Switching: An In-Silico Study, Cardiovascular and Hematological Disorders - Drug Targets (2022)
Experts (# of related papers)
View all Related Experts
Zahra Salehi (4)
Abbas Shakoori farahani (3)
Other Related Docs
9. Construction of Circrna-Mirna-Mrna Network in the Pathogenesis of Recurrent Implantation Failure Using Integrated Bioinformatics Study, Journal of Cellular and Molecular Medicine (2022)
10. Potential Role of Rab6c-As1 Long Noncoding Rna in Different Cancers, Journal of Cellular Physiology (2018)
11. Mirna-Related Polymorphisms in Mir-423 (Rs6505162) and Pex6 (Rs1129186) and Risk of Esophageal Squamous Cell Carcinoma in an Iranian Cohort, Genetic Testing and Molecular Biomarkers (2017)
12. Identification of Lncpvt1 and Circpvt1 As Prognostic Biomarkers in Human Colorectal Polyps, Scientific Reports (2023)
13. A Comprehensive Review on Oncogenic Mirnas in Breast Cancer, Journal of Genetics (2021)
14. Plasma Mir-21, Mir-155, Mir-10B, and Let-7A As the Potential Biomarkers for the Monitoring of Breast Cancer Patients, Scientific Reports (2018)
15. Long Non-Coding Rnas in Diagnosis, Treatment, Prognosis, and Progression of Glioma: A State-Of-The-Art Review, Frontiers in Oncology (2021)
16. Molecular Mechanisms of Long Non-Coding Rnas in Anaplastic Thyroid Cancer: A Systematic Review, Cancer Cell International (2020)
17. Upregulation of Lnc-Foxd2-As1, Cdc45, and Cdk1 in Patients With Primary Non-M3 Aml Is Associated With a Worse Prognosis, Blood Research (2024)
18. The Hsa-Mir-3613–5P, a Potential Oncogene Correlated With Diagnostic and Prognostic Merits in Kidney Renal Clear Cell Carcinoma, Pathology Research and Practice (2023)
19. Differential Expression of Angiogenesis-Related Genes ‘Vegf’ and ‘Angiopoietin-1’ in Metastatic and Emast-Positive Colorectal Cancer Patients, Scientific Reports (2024)
20. Cancer Chemo-Preventive Effects of Red Propolis: A System Biology Approach, Research Journal of Pharmacognosy (2023)
21. Data Mining of Bulk and Single-Cell Rna Sequencing Introduces Obi1-As1 As an Astrocyte Marker With Possible Role in Glioma Recurrence and Progression, Clinical Epigenetics (2022)
22. Mir-17-92A-1 Cluster Host Gene: A Key Regulator in Colorectal Cancer Development and Progression, Clinical and Experimental Medicine (2024)
23. Agonist/Antagonist Compounds' Mechanism of Action on Estrogen Receptor-Positive Breast Cancer: A System-Level Investigation Assisted by Meta-Analysis, Informatics in Medicine Unlocked (2022)
24. A Meta-Analysis of Gene Expression Data Highlights Synaptic Dysfunction in the Hippocampus of Brains With Alzheimer’S Disease, Scientific Reports (2020)
25. Integrated Bioinformatics and Wet-Lab Analysis Revealed Cell Adhesion Prominent Genes Cdc42, Tagln and Gsn As Prognostic Biomarkers in Colonic-Polyp Lesions, Scientific Reports (2023)
26. Prediction of Novel Biomarkers for Gastric Intestinal Metaplasia and Gastric Adenocarcinoma Using Bioinformatics Analysis, Heliyon (2024)
27. In-Silico Engineering of Rna Nanoplatforms to Promote the Diabetic Wound Healing, BMC Chemistry (2023)
28. Bioinformatic Analysis Reveals in Common Genes Between Colorectal Cancer and Recurrent Colorectal Malignancy, Gene Reports (2021)
29. Comparative Proteomic Profiling of Leishmania Tropica: Investigation of a Case Infected With Simultaneous Cutaneous and Viscerotropic Leishmaniasis by 2-Dimentional Electrophoresis and Mass Spectrometry, Iranian Journal of Parasitology (2015)
30. Haplotypic Variants of Covid-19 Related Genes Are Associated With Blood Pressure and Metabolites Levels, Journal of Medical Virology (2023)
31. Identification of Mir-125A As a Novel Plasma Diagnostic Biomarker for Chronic Lymphoblastic Leukemia, Clinical Laboratory (2019)