The Effects of Probiotic Supplements on Oxidative Stress and Inflammation in Subjects With Mild and Moderate Alzheimer’S Disease: A Randomized, Double-Blind, Placebo-Controlled Study Publisher Pubmed

Summary: Probiotic supplements (L. rhamnosus HA-114 & B. longum R0175) significantly reduced oxidative stress and inflammation in mild/moderate Alzheimer's patients in a 12-week randomized trial, improving quality of life and physical activity (P < 0.05)

Akhgarjand C¹ ; Vahabi Z^{2, 3} ; Shabbidar S⁴ ; Anoushirvani A⁵ ; Djafarian K¹
Source: Inflammopharmacology Published:2024

Abstract

Through modulating effects on the gut-brain axis, probiotics are an effective adjuvant treatment for Alzheimer’s disease (AD), one of our century’s most important medical care challenges (Agahi et al. Front Neurol 9:662, 2018). This trial aimed to examine the effects of two different single-strain probiotics on oxidative stress and inflammation in patients with mild and moderate AD. This was a 12-week placebo-controlled, double-blind, randomized clinical trial performed on 90 patients with AD. Eligible patients were randomly assigned to two different interventions (Lacticaseibacillus rhamnosus HA-114 (7.5 × 109) or Bifidobacterium longum R0175 (7.5 × 109)) and a placebo group, supplemented twice daily. We used mixed-effect models to examine the probiotic’s independent effects on clinical results. Significant improvements in serum inflammatory and oxidative stress markers were observed at the end of the trial (P < 0.05). Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.