Exploring the Effect of Gut Microbiome on Alzheimer's Disease Publisher



Pourahmad R^{1, 2, 9} ; Saleki K^{3, 4, 5, 9} ; Zare Gholinejad M^{1, 9} ; Aram C⁶ ; Soltani Farsani A¹ ; Banazadeh M⁷ ; Tafakhori A⁸ Show Affiliations
Source: Biochemistry and Biophysics Reports Published:2024

Abstract

Alzheimer's disease (AD) is the most widespread and irreversible form of dementia and accounts for more than half of dementia cases. The most significant risk factors for AD are aging-related exacerbations, degradation of anatomical pathways, environmental variables and mitochondrial dysfunction. Finding a decisive therapeutic solution is a major current issue. Nuanced interactions between major neuropathological mechanisms in AD in patients and microbiome have recently gained rising attention. The presence of bacterial amyloid in the gut triggers the immune system, resulting in increased immune feedbacks and endogenous neuronal amyloid within the CNS. Also, early clinical research revealed that changing the microbiome with beneficial bacteria or probiotics could affect brain function in AD. New approaches focus on the possible neuroprotective action of disease-modifying medications in AD. In the present review, we discuss the impact of the gut microbiota on the brain and review emerging research that suggests a disruption in the microbiota-brain axis can affect AD by mediating neuroinflammation. Such novel methods could help the development of novel therapeutics for AD. © 2024 The Authors