Novel Delivery Based Anionic Linear Globular Dendrimerg2-Zidovudine Nano-Conjugate Significantly Decreased Retroviral Activity Publisher Pubmed



Pargoo EM¹ ; Aghasadeghi MR³ ; Parivar K¹ ; Bolhassani A³ ; Nikbin M⁴ ; Rahimi P³ ; Ardestani MS² Show Affiliations
Source: Pakistan Journal of Pharmaceutical Sciences Published:2020

Abstract

Human diseases like viral organisms for example, hepatitis, HIV and etc., attack the health and caused large mortality in populations by many years. So finding novel delivery vehicles based antiviral drugs employing nano-materials is of high universal interest. In current approach a very biocompatible biodegradable nano-biopolymer anionic linear globular dendrimer second generation G2 was elaborately conjugated to a well-known anti-HIV drug Azidovudine and thereafter was characterized by different analytical techniques like AFM, Zeta sizer, 1HNMR, FTIR and LC-Mass spectroscopy. Then, Anionic Linear Globular DendrimerG2-Zidovudine Nano-Conjugate was assessed on human normal cells (toxicity assay by XTT test) and also HIV cell model and the results showed that Anionic Linear Globular DendrimerG2-Zidovudine Nano-Conjugate Significantly Decreased Retroviral Activity without any human cell toxicity respectively. Based on current experimental data such nano-compositions is proposed for further in vivo anti-HIV assays as well. © 2020 Pakistan Journal of Pharmaceutical Sciences. All rights reserved.