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Comparison of the Tuberculin Skin Test and the Quantiferon-Tb Gold Test in Detecting Latent Tuberculosis in Health Care Workers in Iran Publisher Pubmed



Mostafavi E1, 2 ; Nasehi M3, 4 ; Shahraki AH1, 2 ; Esmaeili S1, 2, 5 ; Ghaderi E6, 7 ; Sharafi S3 ; Doostiirani A1, 8
Authors
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Authors Affiliations
  1. 1. Department of Epidemiology, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Akanlu, Kabudar-Ahang, Hamadan, Iran
  3. 3. Center for Diseases Control and Prevention, Ministry of Health and Medical Education, Tehran, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
  7. 7. Department of Epidemiology and Biostatistics, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  8. 8. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Epidemiology and Health Published:2021


Abstract

OBJECTIVES: The tuberculin skin test (TST) and the QuantiFERON-TB Gold test (QFT) are used to identify latent tuberculosis infections (LTBIs). The aim of this study was to determine the agreement between these two tests among health care workers in Iran. METHODS: This cross-sectional study included 177 tuberculosis (TB) laboratory staff and 67 non-TB staff. TST indurations of 10 mm or more were considered positive. The Student's t-test and the chi-square test were used to compare the mean score and proportion of variables between the TB laboratory staff and the non-TB laboratory staff. Kappa statistics were used to evaluate the agreement between these tests, and logistic regression was used to assess the risk factors associated with positive results for each test. RESULTS: The prevalence of LTBIs according to both the QFT and the TST was 17% (95% confidence interval [CI], 12% to 21%) and 16% (95% CI, 11% to 21%), respectively. The agreement between the QFT and the TST was 77.46%, with a kappa of 0.19 (95% CI, 0.04 to 0.34). CONCLUSIONS: Although the prevalence of LTBI based on the QFT and the TST was not significantly different, the kappa statistic was low between these two tests for the detection of LTBIs. © 2016, Korean Society of Epidemiology
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