Utility of Quantiferon-Tb Gold In-Tube Test in the Diagnosis of Latent Tb in Hiv-Positive Patients in a Medium-Tb Burden Country Publisher Pubmed



Khazraiyan H¹ ; Liaei ZA¹ ; Koochak HE¹ ; Ardalan FA² ; Ahmadinejad Z¹ ; Soltani A³ Show Affiliations
Source: Journal of the International Association of Providers of AIDS Care Published:2016

Abstract

Background: The authors aimed to compare TST with QuantiFERON-TB Gold In-Tube (QFT) for detecting latent tuberculosis infection (LTBI) in HIV-infected patients in Iran as a TB-medium endemic country. Methods: In a cross-sectional design,130 HIV-positive patients in HIV clinic of Tehran University were studied. Patients screened for LTBI with QFT and TST simultaneously. Concordance between 2 tests results and variables associated with tests discordance were assessed. Results: Positive results found in 24.6% for TST and 7.7% for QFT. Overall agreement between them was 73.85% (Kappa = 0.083). History of imprisonment was associated with more positive TST (P = 0.014) and QFT (P = 0.01). Patients with intravenous drug use (IDU) history had significant discordant results (0.018). Conclusion: The authors recommend QFT for all negative cases of TST in HIV-positive patients especially who had history of IDU. © The Author(s) 2014.