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Performance of First-Trimester Fetal Nuchal Translucency, Ductus Venosus, Tricuspid Regurgitation in Diagnosing Congenital Heart Defects: A Systematic Review and Meta-Analysis Publisher



Moradi B1, 2 ; Jannatdoust P3 ; Shafiekhani P4 ; Tahamtan M1, 5 ; Tavakoli GM3 ; Valizadeh P3 ; Ebrahimi P6 ; Eshaghhosseiny N7 ; Moodi F8 ; Ghorani H1, 9 ; Kohnepoushi P10 ; Razaghi M11 ; Taheri MS12 ; Ghadimi DJ9
Authors
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Authors Affiliations
  1. 1. Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Science, Tehran, Iran
  2. 2. Department of Radiology, Yas Complex Hospital, Tehran University of Medical Science, Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Radiology, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Tehran Heart Center, Cardiovascular Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. School of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  8. 8. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  9. 9. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
  11. 11. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  12. 12. Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Progress in Pediatric Cardiology Published:2025


Abstract

Background: Congenital heart disease (CHD) is the main cause of perinatal morbidity and mortality. Nuchal Translucency (NT), Ductus Venosus (DV), and Tricuspid Regurgitation (TR) have shown potential in CHD detection. Aim of review: We evaluated the pooled diagnostic test accuracy of these markers during the first-trimester screening. Key scientific concepts of review: PubMed, Scopus, Web of Science, and Embase were searched. A bivariate random effects model created Summary Receiver Operating Characteristic (SROC) curves and the pooled sensitivities and specificities. Forty-two studies were included. For major CHDs, the pooled sensitivities and specificities were 43.1 % (95 % CI: 35.0 %–51.6 %) and 95.5 % (95 % CI: 93.5 %–96.9 %) for A/R DV a wave, 57.8 % (95 % CI: 43.3 %–71.0 %) and 88.8 % (95 % CI: 77.7 %–94.7 %) for abnormal DV-PIV, 37.0 % (95 % CI: 26.6 %–48.6 %) and 97.7 % (95 % CI: 94.6 %–99.1 %) for TR, 41.4 % (95 % CI: 23.2 %–62.2 %) and 93.7 % (95 % CI: 92.7 %–94.6 %) for NT > 95th percentile, and 26.6 % (95 % CI: 11.0 %–51.7 %) and 98.3 % (95 % CI: 97.5 %–98.9 %) for NT > 99th percentile. For the combined models in detecting major CHDs, the highest specificity of 97.8 % (95 % CI: 93.9 %–99.2 %) belonged to NT > 95th percentile and A/R DV a wave. The most sensitive tests were the combination of NT > 95th percentile or A/R DV a wave or TR 61.4 % (95 % CI: 49.7 %–71.9 %). Combining increased NT with the presence of A/R a-wave can help diagnose CHD, while normal NT, A/R DV a wave, and TR indicate lower CHD risk. © 2025 Elsevier B.V.
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