Synthesis and Characterization of Novel Phthalimide-Pyrano[3,2-C]Chromene and Phthalimide-Pyrano-2-One Hybrids

Synthesis and Characterization of Novel Phthalimide-Pyrano[3,2-C]Chromene and Phthalimide-Pyrano-2-One Hybrids Publisher

Sameem B¹ ; Saeedi M^{2, 3} ; Mahdavi M⁴ ; Nadri H⁵ ; Vafadarnejad F⁶ ; Amini M^{4, 6}

Show Affiliations

1. Faculty of Pharmacy, International Campus (TUMS-IC) and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Heterocyclic Chemistry Published:2018

Abstract

Coumarin skelton holds substantial promise for further exploration because of its immense pharmacological potential. In this pursuit, a series of phthalimide-chromen and phthalimide-pyran-2-one hybrids were synthesized in efficient yields via one-pot multicomponent reaction of aldehyde linked to phthalimide moiety, 4-hydroxy coumarin/4-hydroxy-6-methyl-2H-pyran-2-one, and malanonitrile by Knoevenagel reaction at room temperature in the presence of DABCO as catalyst. The compounds were characterized by 1H NMR and 13C NMR, MS, and FTIR. All the compounds consisting of phthalimide-chromen/pyrano-2-one moieties tethered by spacers of varying lengths were evaluated for their biological activity in Ellman's assay. Most of the compounds feebly inhibited Acetylcholinesterase Enzyme and were inactive toward Butyrylcholinesterase Enzyme. © 2018 Wiley Periodicals, Inc.

Style	Citing Format
MLA	Sameem B, et al.. "Synthesis and Characterization of Novel Phthalimide-Pyrano[3,2-C]Chromene and Phthalimide-Pyrano-2-One Hybrids." Journal of Heterocyclic Chemistry, vol. 55, no. 7, 2018, pp. 1678-1684.
APA	Sameem B, Saeedi M, Mahdavi M, Nadri H, Vafadarnejad F, Amini M (2018). Synthesis and Characterization of Novel Phthalimide-Pyrano[3,2-C]Chromene and Phthalimide-Pyrano-2-One Hybrids. Journal of Heterocyclic Chemistry, 55(7), 1678-1684.
Chicago	Sameem B, Saeedi M, Mahdavi M, Nadri H, Vafadarnejad F, Amini M. "Synthesis and Characterization of Novel Phthalimide-Pyrano[3,2-C]Chromene and Phthalimide-Pyrano-2-One Hybrids." Journal of Heterocyclic Chemistry 55, no. 7 (2018): 1678-1684.
Harvard	Sameem B et al. (2018) 'Synthesis and Characterization of Novel Phthalimide-Pyrano[3,2-C]Chromene and Phthalimide-Pyrano-2-One Hybrids', Journal of Heterocyclic Chemistry, 55(7), pp. 1678-1684.
Vancouver	Sameem B, Saeedi M, Mahdavi M, Nadri H, Vafadarnejad F, Amini M. Synthesis and Characterization of Novel Phthalimide-Pyrano[3,2-C]Chromene and Phthalimide-Pyrano-2-One Hybrids. Journal of Heterocyclic Chemistry. 2018;55(7):1678-1684.
BibTex	@article{ author = {Sameem B and Saeedi M and Mahdavi M and Nadri H and Vafadarnejad F and Amini M}, title = {Synthesis and Characterization of Novel Phthalimide-Pyrano[3,2-C]Chromene and Phthalimide-Pyrano-2-One Hybrids}, journal = {Journal of Heterocyclic Chemistry}, volume = {55}, number = {7}, pages = {1678-1684}, year = {2018} }
RIS	TY - JOUR AU - Sameem B AU - Saeedi M AU - Mahdavi M AU - Nadri H AU - Vafadarnejad F AU - Amini M TI - Synthesis and Characterization of Novel Phthalimide-Pyrano[3,2-C]Chromene and Phthalimide-Pyrano-2-One Hybrids JO - Journal of Heterocyclic Chemistry VL - 55 IS - 7 SP - 1678 EP - 1684 PY - 2018 ER -

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