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Anti-Rheumatic Activity of Topical Nanoemulsion Containing Bee Venom in Rats Publisher Pubmed



Yousefpoor Y1, 2 ; Amani A3, 4 ; Divsalar A5 ; Mousavi SE6 ; Shakeri A7 ; Sabzevari JT7
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
  3. 3. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
  4. 4. Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  6. 6. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Khalil Abad Health Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: European Journal of Pharmaceutics and Biopharmaceutics Published:2022


Abstract

Purpose: Bee Venom (BV) has been used to treat rheumatoid arthritis (RA) for many centuries. However, its clinical use is limited by pain and fear of bee stings/injection. Nanoemulsions (NEs) are nanocarriers that are able to help their content(s) penetrate through the skin. They also act as drug reservoirs on the skin to provide an efficient, sustained-release vehicle. Methods: In this paper, we present the development of a stable water-in-oil NE to help passing BV through the animal skin when used topically. Results: Particle size of NE was 12.7 to 29.8 nm for NEs containing 0 to 150 µg/ml BV. Also, its anti-inflammatory effects were evaluated in rat models of type II collagen-induced arthritis. Topical administration of NEs containing 18.75 or 9.37 μg/ml BV were able to significantly (p < 0.05) reduce inflammation in the rat paws compared to the blank and control groups. Conclusion: Our findings demonstrated the efficacy of NEs containing BV to reduce inflammation caused by RA animal model. © 2022 Elsevier B.V.
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