Evaluation of the Expression of Mir-486-3P, Mir-548-3P, Mir-561-5P and Mir-509-5P in Tumor Biopsies of Patients With Oral Squamous Cell Carcinoma

Evaluation of the Expression of Mir-486-3P, Mir-548-3P, Mir-561-5P and Mir-509-5P in Tumor Biopsies of Patients With Oral Squamous Cell Carcinoma Publisher

Garajei A^{1, 2} ; Parvin M³ ; Mohammadi H⁴ ; Allameh A⁵ ; Hamidavi A⁵ ; Sadeghi M⁶ ; Emami A⁷ ; Brand S^{8, 9, 10, 11, 12}

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1. Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
2. Department of Head and Neck Surgical Oncology and Reconstructive Surgery, Cancer Institute, School of Medicine, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
3. Department of Oral and Maxillofacial Surgery, School of Dentistry, Bushehr University of Medical Sciences, Bushehr, 7514633341, Iran
4. Department of Oral and Maxillofacial Surgery, Fellowship in Maxillofacial Trauma, Health Services, Kurdistan University of Medical Sciences, Sanandaj, 6617713446, Iran
5. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, 1416753955, Iran
6. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, 1416753955, Iran
7. Department of Anesthesiology, School of Medicine, Iran University of Medical Sciences, Tehran, 1416753955, Iran
8. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6719851115, Iran
9. Center for Affective, Stress and Sleep Disorders, University of Basel, Psychiatric Clinics, Basel, 4002, Switzerland
10. Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran
11. Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, 4052, Switzerland
12. School of Medicine, Tehran University of Medical Sciences, Tehran, 1416753955, Iran

Source: Pathogens Published:2022

Abstract

Background and objective: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Expression patterns of microRNAs (miRNAs) can direct us in identifying valuable biomarkers for the prognosis of different neoplasms. Inappropriate regulation of miRNAs during physiological procedures can result in malignancies including OSCC. The aim of the present study was to evaluate the expression of miR-486-3p, miR-561-5p, miR-548-3p, and miR-509-5p in tissue biopsy samples with and without OSCC. Materials and methods: This case-control study was conducted on 17 healthy and 17 OSCC tissue biopsy samples. The expression of miRNAs was assessed using quantitative real-time PCR (q-RT-PCR) after RNA extraction from normal and cancer tissues and cDNA synthesis. Results: The means of miRNA-486-3p, miR-561-5p, and miR-548-3p expression were significantly different between OSCC and control groups (p < 0.001), but there was no significant difference in means of miR-509-5p expression between OSCC and control groups (p = 0.179). Conclusion: The findings of this study revealed that the expression of miR-486-3p and miR-561-5p was significantly lower in cancer samples compared to normal tissue samples. On the other hand, miR-548-3p expression increased in the OSCC group compared to the control group. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

2. Identification of Common Salivary Mirna in Oral Lichen Planus and Oral Squamous Cell Carcinoma: Systematic Review and Meta-Analysis, BMC Oral Health (2024)

3. Integrated Bioinformatics Analysis of Mrnas and Mirnas Identified Potential Biomarkers of Oral Squamous Cell Carcinoma, Asian Pacific Journal of Cancer Prevention (2020)

4. Mir-155, Mir-191, and Mir-494 As Diagnostic Biomarkers for Oral Squamous Cell Carcinoma and the Effects of Avastin on These Biomarkers, Journal of the Korean Association of Oral and Maxillofacial Surgeons (2020)

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Naghmeh Bahrami (1)

Ata Garajei (1)

Style	Citing Format
MLA	Garajei A, et al.. "Evaluation of the Expression of Mir-486-3P, Mir-548-3P, Mir-561-5P and Mir-509-5P in Tumor Biopsies of Patients With Oral Squamous Cell Carcinoma." Pathogens, vol. 11, no. 2, 2022, pp. -.
APA	Garajei A, Parvin M, Mohammadi H, Allameh A, Hamidavi A, Sadeghi M, Emami A, Brand S (2022). Evaluation of the Expression of Mir-486-3P, Mir-548-3P, Mir-561-5P and Mir-509-5P in Tumor Biopsies of Patients With Oral Squamous Cell Carcinoma. Pathogens, 11(2), -.
Chicago	Garajei A, Parvin M, Mohammadi H, Allameh A, Hamidavi A, Sadeghi M, Emami A, Brand S. "Evaluation of the Expression of Mir-486-3P, Mir-548-3P, Mir-561-5P and Mir-509-5P in Tumor Biopsies of Patients With Oral Squamous Cell Carcinoma." Pathogens 11, no. 2 (2022): -.
Harvard	Garajei A et al. (2022) 'Evaluation of the Expression of Mir-486-3P, Mir-548-3P, Mir-561-5P and Mir-509-5P in Tumor Biopsies of Patients With Oral Squamous Cell Carcinoma', Pathogens, 11(2), pp. -.
Vancouver	Garajei A, Parvin M, Mohammadi H, Allameh A, Hamidavi A, Sadeghi M, et al.. Evaluation of the Expression of Mir-486-3P, Mir-548-3P, Mir-561-5P and Mir-509-5P in Tumor Biopsies of Patients With Oral Squamous Cell Carcinoma. Pathogens. 2022;11(2):-.
BibTex	@article{ author = {Garajei A and Parvin M and Mohammadi H and Allameh A and Hamidavi A and Sadeghi M and Emami A and Brand S}, title = {Evaluation of the Expression of Mir-486-3P, Mir-548-3P, Mir-561-5P and Mir-509-5P in Tumor Biopsies of Patients With Oral Squamous Cell Carcinoma}, journal = {Pathogens}, volume = {11}, number = {2}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Garajei A AU - Parvin M AU - Mohammadi H AU - Allameh A AU - Hamidavi A AU - Sadeghi M AU - Emami A AU - Brand S TI - Evaluation of the Expression of Mir-486-3P, Mir-548-3P, Mir-561-5P and Mir-509-5P in Tumor Biopsies of Patients With Oral Squamous Cell Carcinoma JO - Pathogens VL - 11 IS - 2 SP - EP - PY - 2022 ER -

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