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Fabrication of Pla/Peg/Mwcnt Electrospun Nanofibrous Scaffolds for Anticancer Drug Delivery Publisher



Anaraki NA1 ; Rad LR2 ; Irani M2, 3 ; Haririan I2, 4
Authors
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Authors Affiliations
  1. 1. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
  2. 2. Medical Biomaterials Research Center (MBRC), Tehran University of Medical Science, Tehran, Iran
  3. 3. Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
  4. 4. Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Applied Polymer Science Published:2015


Abstract

In the present study, polylactic acid (PLA)/polyethylene glycol (PEG)/multiwalled carbon nanotube (MWCNT) electrospun nanofibrous scaffolds were prepared via electrospinning process and their applications for the anticancer drug delivery system were investigated. A response surface methodology based on Box-Behnken design (BBD) was used to evaluate the effect of key parameters of electrospinning process including solution concentration, feeding rate, tip-collector distance (TCD) and applied voltage on the morphology of PLA/PEG/MWCNT nanofibrous scaffolds. In optimum conditions (concentration of 8.15%, feeding rate of 0.2 mL/h, voltage of 18.50 kV and TCD of 13.0 cm), the minimum experimental fiber diameter was found to be 225 nm which was in good agreement with the predicted value by the BBD analysis (228 nm). In vitro drug release study of doxorubicin (DOX)-loaded nanofibrous scaffolds, higher drug content induced an extended release of drug. Also, drug release rate was not dependent on drug/polymer ratio in different electrospun nanofibrous formulations. The equation of Mt = c0 + kt0.5 was used to describe the kinetic data of DOX release from electrospun nanofibers. The cell viability of DOX-loaded nanofibrous scaffolds was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole assay on lung cancer A549 cell lines. We propose that DOX-incorporated PLA/PEG/MWCNT nanofibrous scaffold could be used as a superior candidate for antitumor drug delivery. © 2014 Wiley Periodicals, Inc.