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Functionalized Silk Fibroin Nanofibers As Drug Carriers: Advantages and Challenges Publisher Pubmed



Farokhi M1 ; Mottaghitalab F2 ; Reis RL3 ; Ramakrishna S4 ; Kundu SC3
Authors
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Authors Affiliations
  1. 1. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. 3Bs Research Group, I3Bs – Research Institute on Biomaterials, Biodegradable and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimaraes, Portugal
  4. 4. Centre for Nanofibers and Nanotechnology, National University of Singapore, Singapore, 117576, Singapore

Source: Journal of Controlled Release Published:2020


Abstract

Electrospinning is well thought of as the most potent nanofiber producing technique, which is applicable in biomedical fields. The generation of electrospun nanofibers as drug carriers has widely been shown much interest over the past years. Electrospun nanofibers meet various advantages as drug delivery platforms including high surface area, acceptable mechanical properties based on the choice of the polymer, high processability, and the possibilities for surface modifications. Silk fibroin protein has gained a great attention as a drug delivery carrier due to ease of purification, sterilization, processability without using chemical crosslinkers, good biocompatibility, tailorable biodegradability, low immunogenicity, and high capacity to stabilize the loaded drugs. These characteristics along with advantageous benefits of electrospinning provide opportunities for producing suitable nanofibers based on silk fibroin for drug delivery purposes. It is also possible to incorporate various functional moieties to the electrospun silk fibroin nanofibers to enhance its biological activities. This review covers the progress in electrospinning of silk fibroin as a drug carrier in recent years. © 2020 Elsevier B.V.
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