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Covid-19: Review of a 21St Century Pandemic From Etiology to Neuro-Psychiatric Implications Publisher Pubmed



Yamamoto V1, 2, 3, 4 ; Bolanos JF1, 2 ; Fiallos J1, 2 ; Strand SE1, 2 ; Morris K1, 2 ; Shahrokhinia S5 ; Cushing TR6 ; Hopp L7 ; Tiwari A1, 8 ; Hariri R1, 9, 10 ; Sokolov R11 ; Wheeler C1, 2, 12 ; Kaushik A13 ; Elsayegh A14 Show All Authors
Authors
  1. Yamamoto V1, 2, 3, 4
  2. Bolanos JF1, 2
  3. Fiallos J1, 2
  4. Strand SE1, 2
  5. Morris K1, 2
  6. Shahrokhinia S5
  7. Cushing TR6
  8. Hopp L7
  9. Tiwari A1, 8
  10. Hariri R1, 9, 10
  11. Sokolov R11
  12. Wheeler C1, 2, 12
  13. Kaushik A13
  14. Elsayegh A14
  15. Eliashiv D1, 15
  16. Hedrick R16
  17. Jafari B17
  18. Johnson JP18, 19
  19. Khorsandi M20
  20. Gonzalez N19
  21. Balakhani G21
  22. Lahiri S22
  23. Ghavidel K23
  24. Amaya M1, 2
  25. Kloor H1
  26. Hussain N1, 24
  27. Huang E21
  28. Cormier J1, 25
  29. Wesson Ashford J1, 26
  30. Wang JC1, 27
  31. Yaghobian S28
  32. Khorrami P29
  33. Shamloo B30
  34. Moon C32
  35. Shadi P28
  36. Kateb B1, 2, 24, 31, 33
Show Affiliations
Authors Affiliations
  1. 1. Society for Brain Mapping and Therapeutics (SBMT), Los Angeles, CA, United States
  2. 2. Brain Mapping Foundation (BMF), Los Angeles, CA, United States
  3. 3. USC Keck School of Medicine, USC Caruso Department of Otolaryngology-Head and Neck Surgery, Los Angeles, CA, United States
  4. 4. USC-Norris Comprehensive Cancer Center, Los Angeles, CA, United States
  5. 5. Cedars-Sinai Medical Center, Department of Nutrition, Los Angeles, CA, United States
  6. 6. UCLA-Cedar-Sinai California Rehabilitation Institute, Los Angeles, CA, United States
  7. 7. Cedars Sinai Medical Center, Department of Ophthalmology, UCLA Jules Stein Eye Institute, Los Angeles, CA, United States
  8. 8. New York University, Department of Neurology, New York, NY, United States
  9. 9. Celularity Corporation, Warren, NJ, United States
  10. 10. Weill Cornell School of Medicine, Department of Neurosurgery, New York, NY, United States
  11. 11. Cedars-Sinai Medical Center, Department of Infectious Disease, Los Angeles, CA, United States
  12. 12. T-NeuroPharma, Albuquerque, NM, United States
  13. 13. NanoBioTech Laboratory, Department of Natural Sciences, Division of Sciences, Arts, and Mathematics, Florida Polytechnic University, Lakeland, FL, United States
  14. 14. Cedars Sinai Medical Center, Department of Pulmonology, Los Angeles, CA, United States
  15. 15. UCLA David Geffen, School of Medicine, Department of Neurology, Los Angeles, CA, United States
  16. 16. Cedars Sinai Medical Center, Department of Psychiatry, Los Angeles, CA, United States
  17. 17. University of California, Irvine, School of Medicine, Department of Medicine, Irvine, CA, United States
  18. 18. Cedars Sinai Medical Center, Spine Institute, Los Angeles, CA, United States
  19. 19. Cedars-Sinai Medical Center, Department of Neurosurgery, Los Angeles, CA, United States
  20. 20. Cedars-Sinai Medical Center, Department of Cardiology, Los Angeles, CA, United States
  21. 21. Cedars-Sinai Medical Center, Department of Nephrology, Los Angeles, CA, United States
  22. 22. Cedars-Sinai Medical Center, Department of Neurology, Los Angeles, CA, United States
  23. 23. University of Tehran School of Medicine, Department of Cardiology, Tehran, Iran
  24. 24. Loma Linda University, Department of Neurosurgery, Loma Linda, CA, United States
  25. 25. Lafayette Surgical Specialty Hospital, Lafayette, LA, United States
  26. 26. Stanford University School of Medicine (Affiliated), Department of Psychiatry and Behavioral Science, Department of Veteran's Affair, Palo Alto, CA, United States
  27. 27. USC-Keck School of Medicine, Department of Orthopedic Surgery, Los Angeles, CA, United States
  28. 28. Cedars-Sinai Medical Center, Department of Internal Medicine, Los Angeles, CA, United States
  29. 29. Cedars Sinai Medical Center, Department of Gastroenterology, Los Angeles, CA, United States
  30. 30. Cedars Sinai Medical Center, Pain Management, Los Angeles, CA, United States
  31. 31. National Center for NanoBioElectronic (NCNBE), Los Angeles, CA, United States
  32. 32. Cedars Sinai Orthopaedic Center, Department of Orthopedics, Los Angeles, CA, United States
  33. 33. Brain Technology and Innovation Park, Los Angeles, CA, United States

Source: Journal of Alzheimer's Disease Published:2020


Abstract

COVID-19 is a severe infectious disease that has claimed >150,000 lives and infected millions in the United States thus far, especially the elderly population. Emerging evidence has shown the virus to cause hemorrhagic and immunologic responses, which impact all organs, including lungs, kidneys, and the brain, as well as extremities. SARS-CoV-2 also affects patients', families', and society's mental health at large. There is growing evidence of re-infection in some patients. The goal of this paper is to provide a comprehensive review of SARS-CoV-2-induced disease, its mechanism of infection, diagnostics, therapeutics, and treatment strategies, while also focusing on less attended aspects by previous studies, including nutritional support, psychological, and rehabilitation of the pandemic and its management. We performed a systematic review of >1,000 articles and included 425 references from online databases, including, PubMed, Google Scholar, and California Baptist University's library. COVID-19 patients go through acute respiratory distress syndrome, cytokine storm, acute hypercoagulable state, and autonomic dysfunction, which must be managed by a multidisciplinary team including nursing, nutrition, and rehabilitation. The elderly population and those who are suffering from Alzheimer's disease and dementia related illnesses seem to be at the higher risk. There are 28 vaccines under development, and new treatment strategies/protocols are being investigated. The future management for COVID-19 should include B-cell and T-cell immunotherapy in combination with emerging prophylaxis. The mental health and illness aspect of COVID-19 are among the most important side effects of this pandemic which requires a national plan for prevention, diagnosis and treatment. © 2020 - IOS Press and the authors. All rights reserved.
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