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Optimization of Electrospinning Parameters for Producing Silk Fibroin/Poly(Ethylene Oxide) Nanofibers Using D-Optimal Method Publisher



Rajabi M1 ; Zahedi P1 ; Hassannejad Z2, 3 ; Haririan I4
Authors
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Authors Affiliations
  1. 1. Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Pediatric Urology and Regenerative Medicine Research Center, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy and Department of Pharmaceutics, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Natural Fibers Published:2019


Abstract

Despite the ease of the electrospinning process of synthetic polymers, the adjustment of several independent variables for natural ones is a complex procedure. In this work, the electrospinning parameters of silk fibroin (SF)/poly(ethylene oxide) (PEO) blends including tip-to-collector distance (X1), applied voltage (X2), flow rate (X3) and SF/PEO ratio (X4) were optimized using the D-optimal method. By considering the response surface plots and interaction graphs as well as observing the scanning electron microscopy (SEM) images, the optimized conditions were set as follows: X1 = 15 cm, X2 = 12 kV, X3 = 1.2 mL/h and X4 = 4. Accordingly, the electrospun SF/PEO nanofibrous sample with uniform morphology and an average diameter of 182 ± 55 nm was obtained. © 2018, © 2018 Taylor & Francis.
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