Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection Publisher Pubmed

Venkatesan S¹ ; Myles PR¹ ; Bolton KJ² ; Muthuri SG³ ; Al Khuwaitir T⁴ ; Anovadiya AP⁵ ; Azzizbaumgartner E⁶ ; Bajjou T⁷ ; Bassetti M⁸ ; Beovic B⁹ ; Bertisch B¹⁰ ; Bonmarin I¹¹ ; Booy R¹² ; Borjaaburto VH¹³ Show All Authors

Venkatesan S¹
Myles PR¹
Bolton KJ²
Muthuri SG³
Al Khuwaitir T⁴
Anovadiya AP⁵
Azzizbaumgartner E⁶
Bajjou T⁷
Bassetti M⁸
Beovic B⁹
Bertisch B¹⁰
Bonmarin I¹¹
Booy R¹²
Borjaaburto VH¹³
Burgmann H¹⁴
Cao B¹⁵
Carratala J¹⁶
Chinbayar T¹⁷
Cilloniz C¹⁸
Denholm JT¹⁹
Dominguez SR²⁰
Duarte PAD²¹
Dubnovraz G²²
Fanella S²³
Gao Z²⁴
Gerardin P^{25, 26, 27}
Giannella M^{28, 29}
Gubbels S³⁰
Herberg J³¹
Higuera Iglesias AL³²
Hoeger PH³³
Hu XY³⁴
Islam QT³⁵
Jimenez MF³⁶
Keijzers G³⁷
Khalili H³⁸
Kusznierz G³⁹
Kuzman I⁴⁰
Langenegger E⁴¹
Lankarani KB⁴²
Leo YS⁴³
Libster RP^{44, 45, 46}
Linko R⁴⁷
Madanat F⁴⁸
Maltezos E⁴⁹
Mamun A⁵⁰
Manabe T⁵¹
Metan G⁵²
Mickiene A⁵³
Mikic D⁵⁴
Mohn KGI^{55, 56}
Oliva ME⁵⁷
Ozkan M⁵⁸
Parekh D⁵⁹
Paul M⁶⁰
Rath BA⁶¹
Refaey S⁶²
Rodriguez AH⁶³
Sertogullarindan B⁶⁴
Skretmagierlo J⁶⁵
Somer A⁶⁶
Talarek E⁶⁷
Tang JW^{68, 69, 70}
To K⁷¹
Tran D⁷²
Uyeki TM⁶
Vaudry W⁷³
Vidmar T⁷⁴
Zarogoulidis P⁷⁵
Nguyenvantam JS¹

Show Affiliations

1. Division of Epidemiology and Public Health, University of Nottingham, Nottingham
2. School of Mathematical Sciences, University of Nottingham, Nottingham
3. MRC Unit for Lifelong Health and Ageing, University College London
4. Department of Medicine, King Saud Medical City, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia
5. Department of Pharmacology, Government Medical College and Sir Takhtasinhji General Hospital, Bhavnagar, India
6. Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
7. University Mohammed V-Souissi, Faculty of Medicine and Pharmacy, Mohammed V Military Teaching Hospital, Biosafety Level 3 and Research Laboratory, Rabat, Morocco
8. Santa Maria Misericordia Hospital, Udine, Italy
9. Department of Infectious Diseases, University Medical Center, Ljubljana, Slovenia
10. Institute of Global Health, University of Geneva, Switzerland
11. Institut de Veille Sanitaire, Saint Maurice, France
12. National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, University of Sydney
13. Instituto Mexicano del Seguro Social
14. Medical University of Vienna, Austria
15. Beijing Chao-Yang Hospital, Capital Medical University
16. Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, Spanish Network for Research in Infectious Diseases
17. National Influenza Center, National Center of Communicable Diseases, Ministry of Health, Ulaanbaatar, Mongolia
18. Hospital Clinic, August Pi I Sunyer Biomedical Research Institute, University of Barcelona, CIBERES, Barcelona, Philippines
19. Victorian Infectious Diseases Service and Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, Parkville, United States
20. Department of Pediatric Infectious Diseases, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, United States
21. Universidade Estadual do Oeste do Parana-UNIOESTE, Cascavel, Brazil
22. Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel
23. Section of Pediatric Infectious Diseases, University of Manitoba, Winnipeg, Canada
24. Department of Respiratory and Critical Care Medicine, Peking University People's Hospital
25. Pole Femme Mere Enfant
26. Center for Clinical Investigation 1410, Institut National de la Sante et de la Recherche Medical (INSERM), Centre Hospitalier Universitaire de la Reunion, Saint Pierre and Miquelon
27. Unite Mixte 134 Processus Infectieux en Milieu Insulaire Tropical, Centre National de la Recherche Scientifique 9192, INSERM U1187, Institut Recherche et Developpement 249, Universite de la Reunion, Sainte Clotilde, Reunion
28. Department of Clinical and Surgical Sciences, Sant'Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
29. Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Madrid, Spain
30. Department of Infectious Disease Epidemiology, Sector for National Health Documentation and Research, Statens Serum Institut, Copenhagen, Denmark
31. Section of Paediatrics, Division of Infectious Disease, Imperial College, London
32. Department of Research in Clinical Epidemiology, Instituto Nacional de Enfermedades Respiratorias Dr. Ismael Cosio Villegas, Mexico City, Mexico
33. Catholic Children's Hospital Wilhelmstift, Hamburg, Germany
34. Peking Union Medical College Hospital, Beijing, China
35. Dhaka Medical College Hospital, Bangladesh
36. Departamento de Ginecologia e Obstetricia-UFCSPA, Preceptora da Residencia Medica do Hospital Femina, Brazil
37. Gold Coast University Hospital, Gold Coast, Australia
38. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
39. National Institute of Respiratory Diseases Emilio Coni ANLIS C. Malbran, Santa Fe
40. University Hospital for Infectious Diseases, University of Zagreb School of Medicine, Croatia
41. Department of Obstetrics and Gynaecology, Cape Town, South Africa
42. Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
43. Department of Infectious Diseases, Tan Tock Seng Hospital
44. Department of Pediatrics, Vanderbilt University, Nashville, TN, United States
45. Fundacion INFANT
46. National Scientific and Technical Research Council, Buenos Aires, Argentina
47. Helsinki University Hospital, Finland
48. Department of Pediatrics, King Hussein Cancer Center, Amman, Jordan
49. Unit of Infectious Diseases, University General Hospital of Alexandroupolis, Democritus University Thrace
50. British Columbia Centre for Disease Control, Vancouver, Canada
51. Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan
52. Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
53. Lithuanian University of Health Sciences, Kaunas, Lithuania
54. Military Medical Academy, Clinic for Infectious and Tropical Diseases, University of Defense, Belgrade, Serbia
55. Influenza Center, Department of Clinical Science, University of Bergen
56. Haukeland University Hospital, Bergen, Norway
57. Department of Infection Control, Hospital San Martin de Parana, Entre Rios, Argentina
58. Pediatric Neurology Department, Bahcesehir University
59. Respiratory and Critical Care Medicine, Institute of Inflammation and Ageing, University of Birmingham, Birmingham
60. Division of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel
61. Department of Pediatrics, Charite-University Medical Center Berlin, Berlin, Germany
62. Epidemiology and Surveillance Department, Ministry of Health and Population, Cairo, Egypt
63. Critical Care Department, Hospital Joan XXIII, Tarragona, Spain
64. Department of Pulmonary Medicine, Medical Faculty, Yuzuncu Yil University, Van, Turkey
65. Uniwersytet Rzeszowski, Rzeszow, Poland
66. Department of Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
67. Department of Children's Infectious Diseases, Medical University of Warsaw, Warsaw, Poland
68. Department of Respiratory Sciences, University of Leicester
69. University Hospitals Leicester, Leicester, United Kingdom
70. Molecular Diagnostic Centre, Department of Laboratory Medicine, National University Hospital, Singapore
71. Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, China
72. Acute and Communicable Disease Prevention, Public Health Division, Oregon Health Authority, Portland, Jamaica
73. Division of Infectious Diseases, Department of Pediatrics, University of Alberta, Stollery Children's Hospital, Edmonton, Canada
74. General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia
75. Pulmonary Department, G. Papanikalaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

Source: The Journal of infectious diseases Published:2020

Abstract

BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded. RESULTS: We analyzed data on 18 309 patients from 70 clinical centers. After adjustment, NAI treatment initiated at hospitalization was associated with a 19% reduction in the LoS among patients with clinically suspected or laboratory-confirmed influenza A(H1N1)pdm09 infection (IRR, 0.81; 95% CI, .78-.85), compared with later or no initiation of NAI treatment. Similar statistically significant associations were seen in all clinical subgroups. NAI treatment (at any time), compared with no NAI treatment, and NAI treatment initiated <2 days after symptom onset, compared with later or no initiation of NAI treatment, showed mixed patterns of association with the LoS. CONCLUSIONS: When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment. © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Style	Citing Format
MLA	Venkatesan S, et al.. "Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection." The Journal of infectious diseases, vol. 221, no. 3, 2020, pp. 356-366.
APA	Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azzizbaumgartner E, Bajjou T, Bassetti M, Beovic B, Bertisch B, Bonmarin I, Booy R, Borjaaburto VH, Burgmann H, Cao B, Carratala J, Chinbayar T, Cilloniz C, ... Nguyenvantam JS (2020). Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection. The Journal of infectious diseases, 221(3), 356-366.
Chicago	Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azzizbaumgartner E, et al.. "Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection." The Journal of infectious diseases 221, no. 3 (2020): 356-366.
Harvard	Venkatesan S et al. (2020) 'Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection', The Journal of infectious diseases, 221(3), pp. 356-366.
Vancouver	Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, et al.. Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection. The Journal of infectious diseases. 2020;221(3):356-366.
BibTex	@article{ author = {Venkatesan S and Myles PR and Bolton KJ and Muthuri SG and Al Khuwaitir T and Anovadiya AP and Azzizbaumgartner E and Bajjou T and Bassetti M and Beovic B and Bertisch B and Bonmarin I and Booy R and Borjaaburto VH and Burgmann H and Cao B and Carratala J and Chinbayar T and Cilloniz C and Denholm JT and Dominguez SR and Duarte PAD and Dubnovraz G and Fanella S and Gao Z and Gerardin P and Giannella M and Gubbels S and Herberg J and Higuera Iglesias AL and Hoeger PH and Hu XY and Islam QT and Jimenez MF and Keijzers G and Khalili H and Kusznierz G and Kuzman I and Langenegger E and Lankarani KB and Leo YS and Libster RP and Linko R and Madanat F and Maltezos E and Mamun A and Manabe T and Metan G and Mickiene A and Mikic D and Mohn KGI and Oliva ME and Ozkan M and Parekh D and Paul M and Rath BA and Refaey S and Rodriguez AH and Sertogullarindan B and Skretmagierlo J and Somer A and Talarek E and Tang JW and To K and Tran D and Uyeki TM and Vaudry W and Vidmar T and Zarogoulidis P and Nguyenvantam JS}, title = {Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection}, journal = {The Journal of infectious diseases}, volume = {221}, number = {3}, pages = {356-366}, year = {2020} }
RIS	TY - JOUR AU - Venkatesan S AU - Myles PR AU - Bolton KJ AU - Muthuri SG AU - Al Khuwaitir T AU - Anovadiya AP AU - Azzizbaumgartner E AU - Bajjou T AU - Bassetti M AU - Beovic B AU - Bertisch B AU - Bonmarin I AU - Booy R AU - Borjaaburto VH AU - Burgmann H AU - Cao B AU - Carratala J AU - Chinbayar T AU - Cilloniz C AU - Denholm JT AU - Dominguez SR AU - Duarte PAD AU - Dubnovraz G AU - Fanella S AU - Gao Z AU - Gerardin P AU - Giannella M AU - Gubbels S AU - Herberg J AU - Higuera Iglesias AL AU - Hoeger PH AU - Hu XY AU - Islam QT AU - Jimenez MF AU - Keijzers G AU - Khalili H AU - Kusznierz G AU - Kuzman I AU - Langenegger E AU - Lankarani KB AU - Leo YS AU - Libster RP AU - Linko R AU - Madanat F AU - Maltezos E AU - Mamun A AU - Manabe T AU - Metan G AU - Mickiene A AU - Mikic D AU - Mohn KGI AU - Oliva ME AU - Ozkan M AU - Parekh D AU - Paul M AU - Rath BA AU - Refaey S AU - Rodriguez AH AU - Sertogullarindan B AU - Skretmagierlo J AU - Somer A AU - Talarek E AU - Tang JW AU - To K AU - Tran D AU - Uyeki TM AU - Vaudry W AU - Vidmar T AU - Zarogoulidis P AU - Nguyenvantam JS TI - Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection JO - The Journal of infectious diseases VL - 221 IS - 3 SP - 356 EP - 366 PY - 2020 ER -

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