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Real Clinical Practice and Therapeutic Management Following Covid-19 Crisis in Two Hospitals in Iran: A Statistical and Conceptual View



Najafi A1 ; Ghanei M2 ; Janbabaei G3 ; Velayati AA4 ; Saadat SH5 ; Jamaati H6 ; Tabarsi P4 ; Dastan F6 ; Ram M7 ; Darabi E8 ; Fathi S9 ; Fesharaki MG10 ; Ghazale AH11 ; Saloo S11
Authors
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Authors Affiliations
  1. 1. Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Department of Hematology Oncology, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Behavioral Sciences Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  6. 6. Chronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Biostatistics, Ferdows Paramedical School, Birjand University of Medical Sciences, Birjand, Iran
  8. 8. School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Postdoctoral Fellow, University of Tehran, Tehran, Iran
  10. 10. Biostatistics Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  11. 11. Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Tanaffos Published:2020

Abstract

Background: The Coronavirus disease 2019 (COVID-19) outbreak quickly has spread and became a pandemic. However, no approved therapeutics or effective treatment is available for the treatment of these patients. The present study was done to retrospectively assess the treatment strategies (e.g., pharmaceutical care services) for COVID-19 patients in selected hospitals and highlight the importance of such services in the management of a pandemic. Materials and Methods: Data from a series of COVID-19 patients (978 patients; 658 males [66.9%] and 324 females [33.1%]) admitted to the selected hospitals in Tehran from 20 February to 19 March 2020 were retrieved retrospectively from the Health Information System (HIS) of the hospitals. The statistical tests were used for analyzing the effect and correlation of the variables (drugs) with the average length of stay (ALOS) in the hospital. Results: Diverse medication classes and old drugs with or without strong evidence of therapeutic effects against the novel coronavirus, some previously tried as a treatment for SARS-CoV and MERS-CoV, were mostly used for the treatment of patients in the hospitals. Many medications (broad-spectrum antibiotics and antivirals) or combination therapies are used without evidence of their therapeutic effects during pandemics. Conclusion: Therefore, guidelines should be provided for the off-label use of these drugs by policymakers and stakeholders during a pandemic emergency due to high demands. Also, monitoring of the HIS data can play an important role in improving public health response to emerging diseases. © 2020 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran.
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