Toxoplasma Gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in Balb/C Mice

Toxoplasma Gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in Balb/C Mice Publisher Pubmed

Mahmoudvand H¹ ; Ziaali N¹ ; Ghazvini H² ; Shojaee S³ ; Keshavarz H³ ; Esmaeilpour K² ; Sheibani V²

Show Affiliations

1. Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
2. Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran
3. Department of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Inflammation Published:2016

Abstract

We hypothesized that in Toxoplasma gondii infection, communication among immune cells promotes neuroinflammation through cytokine networks and induces pain sensitivity under conditions of neuropathic pain. The animal model of Toxoplasma infection was established by the intraperitoneal inoculation of 20–25 tissue cysts from Tehran strain of T. gondii to BALB/c mice. Amitriptyline (20 mg/kg, i.p., 1/day) administrated to animals for 7 days before behavioral tests. Pain behavioral tests including tail flick, hot plate, and formalin test were evaluated in all the groups. The mRNA levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were examined by real-time PCR. Results revealed that T. gondii induce hyperalgesia in the infected mice, whereas amitriptyline showed a promising effect against the hyperalgesia induced by Toxoplasma infection. The mRNA levels of the aforementioned cytokines significantly (P < 0.05) increased in the infected mice compared to the uninfected ones. Obtained findings suggested that T. gondii infection could promote neuroinflammation through cytokine networks and induced hyperalgesia in BALB/c mice, whereas amitriptyline as an analgesic drug reverses them. © 2015, Springer Science+Business Media New York.

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Saeedeh Shojaee (5)

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Style	Citing Format
MLA	Mahmoudvand H, et al.. "Toxoplasma Gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in Balb/C Mice." Inflammation, vol. 39, no. 1, 2016, pp. 405-412.
APA	Mahmoudvand H, Ziaali N, Ghazvini H, Shojaee S, Keshavarz H, Esmaeilpour K, Sheibani V (2016). Toxoplasma Gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in Balb/C Mice. Inflammation, 39(1), 405-412.
Chicago	Mahmoudvand H, Ziaali N, Ghazvini H, Shojaee S, Keshavarz H, Esmaeilpour K, Sheibani V. "Toxoplasma Gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in Balb/C Mice." Inflammation 39, no. 1 (2016): 405-412.
Harvard	Mahmoudvand H et al. (2016) 'Toxoplasma Gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in Balb/C Mice', Inflammation, 39(1), pp. 405-412.
Vancouver	Mahmoudvand H, Ziaali N, Ghazvini H, Shojaee S, Keshavarz H, Esmaeilpour K, et al.. Toxoplasma Gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in Balb/C Mice. Inflammation. 2016;39(1):405-412.
BibTex	@article{ author = {Mahmoudvand H and Ziaali N and Ghazvini H and Shojaee S and Keshavarz H and Esmaeilpour K and Sheibani V}, title = {Toxoplasma Gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in Balb/C Mice}, journal = {Inflammation}, volume = {39}, number = {1}, pages = {405-412}, year = {2016} }
RIS	TY - JOUR AU - Mahmoudvand H AU - Ziaali N AU - Ghazvini H AU - Shojaee S AU - Keshavarz H AU - Esmaeilpour K AU - Sheibani V TI - Toxoplasma Gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in Balb/C Mice JO - Inflammation VL - 39 IS - 1 SP - 405 EP - 412 PY - 2016 ER -

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