Resveratrol Suppresses Hyperglycemia-Induced Activation of Nf-Κb and Ap-1 Via C-Jun and Rela Gene Regulation

Resveratrol Suppresses Hyperglycemia-Induced Activation of Nf-Κb and Ap-1 Via C-Jun and Rela Gene Regulation Publisher

Mohammadpour Z^{1, 2} ; Amiri F³ ; Sabooryaraghi AA⁴ ; Koohdani F¹ ; Norouzzadeh M¹ ; Sharifi L¹ ; Seyyedsalehi M¹ ; Ebrahimi A² ; Mahmoudi M^{1, 5, 6}

Show Affiliations

1. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetic, Tehran University of Medical Sciences, Tehran, Iran
2. Liver Transplantation Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
4. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5. Pediatric Gastroenterology and Hepatology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
6. Dietetics and Nutrition Experts Team (DiNET), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Medical Journal of the Islamic Republic of Iran Published:2018

Abstract

Background: Resveratrol (RSV) provides several important biological functions in wide variety of cells. In this study, we investigated the molecular mechanisms underlying anti-inflammatory effect of RSV on HepG2 cells by assessing the gene expression of RelA and c-Jun- subunits of NF-κB and AP-1 transcription factors. Methods: HepG2 cells were settled in a serum- free medium with high concentrations of glucose (30 mM) and insulin (1 μM) overnight and were then incubated with RSV (5, 10, and 20 μM) for 24 and 48 hours. Real time quantitative polymerase chain reaction (qRT-PCR) was used to determine RelA and c-Jun expression. Results: RSV diminished hyperglycemia/hyperinsulinemia stimulated expression of c-Jun dose- dependently after 24 and 48 hours (p < 0.05). In addition, RelA gene expression was decreased dose-dependently in all RSV doses after 48-hour incubation (p < 0.05). Our results indicated that RSV may reduce NF-κB and AP-1 activity via RelA and c-Jun gene regulation. Conclusion: The findings of the present study demonstrated that RSV may be considered as a preventative and therapeutic agent for antagonizing inflammation in Hepatocellular carcinoma (HCC). © Iran University of Medical Sciences.

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Style	Citing Format
MLA	Mohammadpour Z, et al.. "Resveratrol Suppresses Hyperglycemia-Induced Activation of Nf-Κb and Ap-1 Via C-Jun and Rela Gene Regulation." Medical Journal of the Islamic Republic of Iran, vol. 32, no. 1, 2018, pp. 51-56.
APA	Mohammadpour Z, Amiri F, Sabooryaraghi AA, Koohdani F, Norouzzadeh M, Sharifi L, Seyyedsalehi M, Ebrahimi A, Mahmoudi M (2018). Resveratrol Suppresses Hyperglycemia-Induced Activation of Nf-Κb and Ap-1 Via C-Jun and Rela Gene Regulation. Medical Journal of the Islamic Republic of Iran, 32(1), 51-56.
Chicago	Mohammadpour Z, Amiri F, Sabooryaraghi AA, Koohdani F, Norouzzadeh M, Sharifi L, Seyyedsalehi M, Ebrahimi A, Mahmoudi M. "Resveratrol Suppresses Hyperglycemia-Induced Activation of Nf-Κb and Ap-1 Via C-Jun and Rela Gene Regulation." Medical Journal of the Islamic Republic of Iran 32, no. 1 (2018): 51-56.
Harvard	Mohammadpour Z et al. (2018) 'Resveratrol Suppresses Hyperglycemia-Induced Activation of Nf-Κb and Ap-1 Via C-Jun and Rela Gene Regulation', Medical Journal of the Islamic Republic of Iran, 32(1), pp. 51-56.
Vancouver	Mohammadpour Z, Amiri F, Sabooryaraghi AA, Koohdani F, Norouzzadeh M, Sharifi L, et al.. Resveratrol Suppresses Hyperglycemia-Induced Activation of Nf-Κb and Ap-1 Via C-Jun and Rela Gene Regulation. Medical Journal of the Islamic Republic of Iran. 2018;32(1):51-56.
BibTex	@article{ author = {Mohammadpour Z and Amiri F and Sabooryaraghi AA and Koohdani F and Norouzzadeh M and Sharifi L and Seyyedsalehi M and Ebrahimi A and Mahmoudi M}, title = {Resveratrol Suppresses Hyperglycemia-Induced Activation of Nf-Κb and Ap-1 Via C-Jun and Rela Gene Regulation}, journal = {Medical Journal of the Islamic Republic of Iran}, volume = {32}, number = {1}, pages = {51-56}, year = {2018} }
RIS	TY - JOUR AU - Mohammadpour Z AU - Amiri F AU - Sabooryaraghi AA AU - Koohdani F AU - Norouzzadeh M AU - Sharifi L AU - Seyyedsalehi M AU - Ebrahimi A AU - Mahmoudi M TI - Resveratrol Suppresses Hyperglycemia-Induced Activation of Nf-Κb and Ap-1 Via C-Jun and Rela Gene Regulation JO - Medical Journal of the Islamic Republic of Iran VL - 32 IS - 1 SP - 51 EP - 56 PY - 2018 ER -

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