Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population

Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population Publisher Pubmed

Shabani M¹ ; Sadeghi A² ; Hosseini H¹ ; Teimouri M¹ ; Babaei Khorzoughi R¹ ; Pasalar P¹ ; Meshkani R¹

Show Affiliations

1. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I.R., Iran
2. Department of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Source: Scientific Reports Published:2020

Abstract

Resveratrol was reported to inhibit inflammatory responses; however, the role of this polyphenol in obesity-induced skeletal muscle inflammation remains unknown. Mice fed a high fat diet (HFD) were treated with resveratrol for 16 weeks. Resveratrol treatment decreased macrophage infiltration into skeletal muscle of HFD-fed mice. Resveratrol also led to the polarization of macrophages to the M2 direction, as well as decreasing the expression of a number of M1 pro-inflammatory cytokines [tumor necrosis factor α (TNF-α), interleukin 1 β (IL-1β) and interleukin 6 (IL-6)]. In addition, increased infiltration of regulatory T cells (Treg cells) was found following resveratrol treatment in skeletal muscle of mice. Decreased intramyocellular lipid deposition was associated with reduced expression levels of toll-like receptors 2 (TLR2) and TLR4 in resveratrol treated mice. We also found that diminished inflammation in skeletal muscle following resveratrol treatment was accompanied by increasing phosphorylation of 5’-adenosine monophosphate-activated protein kinase (AMPK) and decreasing phosphorylation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK). Taken together, these findings suggest that resveratrol ameliorates inflammation in skeletal muscle of HFD-induced model of obesity. Therefore, resveratrol might represent a potential treatment for attenuation of inflammation in skeletal muscle tissue. © 2020, The Author(s).

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Style	Citing Format
MLA	Shabani M, et al.. "Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population." Scientific Reports, vol. 10, no. 1, 2020, pp. -.
APA	Shabani M, Sadeghi A, Hosseini H, Teimouri M, Babaei Khorzoughi R, Pasalar P, Meshkani R (2020). Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population. Scientific Reports, 10(1), -.
Chicago	Shabani M, Sadeghi A, Hosseini H, Teimouri M, Babaei Khorzoughi R, Pasalar P, Meshkani R. "Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population." Scientific Reports 10, no. 1 (2020): -.
Harvard	Shabani M et al. (2020) 'Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population', Scientific Reports, 10(1), pp. -.
Vancouver	Shabani M, Sadeghi A, Hosseini H, Teimouri M, Babaei Khorzoughi R, Pasalar P, et al.. Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population. Scientific Reports. 2020;10(1):-.
BibTex	@article{ author = {Shabani M and Sadeghi A and Hosseini H and Teimouri M and Babaei Khorzoughi R and Pasalar P and Meshkani R}, title = {Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population}, journal = {Scientific Reports}, volume = {10}, number = {1}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Shabani M AU - Sadeghi A AU - Hosseini H AU - Teimouri M AU - Babaei Khorzoughi R AU - Pasalar P AU - Meshkani R TI - Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population JO - Scientific Reports VL - 10 IS - 1 SP - EP - PY - 2020 ER -

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