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The Potential of Cannabidiol for Acute Respiratory Distress Syndrome in Covid-19 Publisher Pubmed



Azimi S1 ; Saghafi F2 ; Mohammadi MH3 ; Moghimi MH4 ; Akhavan SA4 ; Khataminia M5 ; Shirvani M6 ; Sohrevardi SM2 ; Jamialahmadi T7 ; Sahebnasagh A8 ; Sahebkar A7, 9
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  4. 4. Student Research Committee, Faculty of Phar-macy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  5. 5. Student Research Committee, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  7. 7. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Department of Internal Medicine, Clinical Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
  9. 9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Current Pharmaceutical Design Published:2023


Abstract

COVID-19 disease manifests itself in a wide range of signs and symptoms, beginning with mild symptoms, such as fever, cough, and dyspnea, progressing to acute respiratory distress syndrome (ARDS) and death in some cases. The cytokine storm, or an excess of cytokines released locally, is assumed to be the pri-mary cause of ARDS and mortality in COVID-19 patients. To enhance the survival rate of COVID-19 pa-tients, early management of the cytokine storm with immunomodulators is crucial. Although the effectiveness of some immunosuppressants, such as corticosteroids and tocilizumab, has been studied in clinical trials, the administration of these drugs should be exercised cautiously. Cannabidiol (CBD) is a non-psychotropic phyto-cannabinoid from Cannabis sativa extracts with anti-inflammatory properties. This review is intended to dis-cuss the possible utility of CBD for the management of COVID-19 patients, particularly those with ARDS. © 2023 Bentham Science Publishers.
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