The Role of Cytokines and Their Antagonists in the Treatment of Covid-19 Patients

The Role of Cytokines and Their Antagonists in the Treatment of Covid-19 Patients Publisher Pubmed

Mohseni Afshar Z¹ ; Barary M^{2, 3} ; Babazadeh A⁴ ; Tavakoli Pirzaman A⁵ ; Hosseinzadeh R⁵ ; Alijanpour A⁶ ; Allahgholipour A⁷ ; Miri SR⁸ ; Sio TT⁹ ; Sullman MJM^{10, 11} ; Carsonchahhoud K¹² ; Ebrahimpour S⁴

Show Affiliations

1. Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
2. Student Research Committee, Virtual School of Medical Education and Management, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
4. Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
5. Student Research Committee, Babol University of Medical Sciences, Babol, Iran
6. Faculty of Medicine, Semmelweis University, Budapest, Hungary
7. Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
9. Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, United States
10. Department of Social Sciences, University of Nicosia, Nicosia, Cyprus
11. Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus
12. Australian Centre for Precision Health, University of South Australia, Adelaide, Australia

Source: Reviews in Medical Virology Published:2023

Abstract

The coronavirus disease 2019 (COVID-19) has various presentations, of which immune dysregulation or the so-called cytokine storm syndrome (COVID-CSS) is prominent. Even though cytokines are vital regulators of body immunoinflammatory responses, their exaggerated release can be harmful. This hyperinflammatory response is more commonly observed during severe COVID-19 infections, caused by the excessive release of pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-6, IL-8, tumour necrosis factor, granulocyte-macrophage colony-stimulating factor, and interferon-gamma, making their blockers and antagonists of great interest as therapeutic options in this condition. Thus, the pathophysiology of excessive cytokine secretion is outlined, and their most important blockers and antagonists are discussed, mainly focussing on tocilizumab, an interleukin-6 receptor blocker approved to treat severe COVID-19 infections. © 2022 John Wiley & Sons Ltd.

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Style	Citing Format
MLA	Mohseni Afshar Z, et al.. "The Role of Cytokines and Their Antagonists in the Treatment of Covid-19 Patients." Reviews in Medical Virology, vol. 33, no. 1, 2023, pp. -.
APA	Mohseni Afshar Z, Barary M, Babazadeh A, Tavakoli Pirzaman A, Hosseinzadeh R, Alijanpour A, Allahgholipour A, Miri SR, Sio TT, Sullman MJM, Carsonchahhoud K, Ebrahimpour S (2023). The Role of Cytokines and Their Antagonists in the Treatment of Covid-19 Patients. Reviews in Medical Virology, 33(1), -.
Chicago	Mohseni Afshar Z, Barary M, Babazadeh A, Tavakoli Pirzaman A, Hosseinzadeh R, Alijanpour A, Allahgholipour A, et al.. "The Role of Cytokines and Their Antagonists in the Treatment of Covid-19 Patients." Reviews in Medical Virology 33, no. 1 (2023): -.
Harvard	Mohseni Afshar Z et al. (2023) 'The Role of Cytokines and Their Antagonists in the Treatment of Covid-19 Patients', Reviews in Medical Virology, 33(1), pp. -.
Vancouver	Mohseni Afshar Z, Barary M, Babazadeh A, Tavakoli Pirzaman A, Hosseinzadeh R, Alijanpour A, et al.. The Role of Cytokines and Their Antagonists in the Treatment of Covid-19 Patients. Reviews in Medical Virology. 2023;33(1):-.
BibTex	@article{ author = {Mohseni Afshar Z and Barary M and Babazadeh A and Tavakoli Pirzaman A and Hosseinzadeh R and Alijanpour A and Allahgholipour A and Miri SR and Sio TT and Sullman MJM and Carsonchahhoud K and Ebrahimpour S}, title = {The Role of Cytokines and Their Antagonists in the Treatment of Covid-19 Patients}, journal = {Reviews in Medical Virology}, volume = {33}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Mohseni Afshar Z AU - Barary M AU - Babazadeh A AU - Tavakoli Pirzaman A AU - Hosseinzadeh R AU - Alijanpour A AU - Allahgholipour A AU - Miri SR AU - Sio TT AU - Sullman MJM AU - Carsonchahhoud K AU - Ebrahimpour S TI - The Role of Cytokines and Their Antagonists in the Treatment of Covid-19 Patients JO - Reviews in Medical Virology VL - 33 IS - 1 SP - EP - PY - 2023 ER -

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