Effects of Calorie Restriction on Multiple Sclerosis: A Review of the Preclinical and Clinical Studies Publisher Pubmed



Javanbakht P¹ ; Taghizadeh F¹ ; Takabi FS² ; Tajik M¹ ; Iranshahi S³ ; Pasbakhsh P¹ ; Kashani IR¹ ; Mojaverrostami S^{1, 4} Show Affiliations
Source: Neurochemical Research Published:2023

Abstract

It has been indicated that calorie restriction (CR) leads to several neuroprotective effects against physiological aging and different neurodegenerative disorders. Unfortunately, the definite therapeutic strategy is not introduced for Multiple sclerosis (MS) as an autoimmune disease of central nervous system (CNS) and researchers are striving to find the best treatment procedures and then optimize them. More recently, several preclinical studies have reported beneficial effects of CR on MS. It was stated that CR can decline demyelination, improve remyelination and decrease neuroinflammation in animal model of MS, as well as reduce body weight and enhance emotional wellbeing in MS patients. In this context we designed this review to examine studies exploring the effects of CR on MS disease based on the clinical and animal models to highlight involved mechanistic implications and future prospective. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.