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Does the Reaction Size of Skin Prick Test Associated With the Allergic Rhinitis Symptom Severity? Publisher Pubmed



Madani S1, 2 ; Zandieh F3 ; Ahmadi M1 ; Parvizi M4 ; Rezaei N5, 6, 7
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of, Medical Sciences, Tehran, Iran
  2. 2. Department of Pediatrics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Allergy Clinic, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pathology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Allergologia et Immunopathologia Published:2021


Abstract

Background: Skin prick test (SPT) has the best positive predictive value to diagnose respiratory atopic diseases, including allergic rhinitis (AR), but the association of severity of allergic symptom and SPT reaction size has not been clearly determined yet. Methods: In this a cross-sectional investigation, the severity of disease is classified using a visual analog scale for main symptoms, and SPT was conducted according to the principles of the European Academy of Allergy and Clinical Immunology. Results: Thirty seven percent of the participants had at least one severe symptom. Patients with sensitivity to Alternaria (common allergens in humans) or tree pollens had more severe symptoms. We found that in patients who had sensitivity to Russian thistle pollen, wheal size >6 mm, was associated with more severe symptoms. Conclusion: Despite previous conflicts to rely on SPT test for starting immunotherapy, we recommend this test especially for patients sensitive to Alternaria, weed pollens, and tree pollens, considering the size of wheal in association with AR symptom severity. © 2021. Codon Publications. Published by Codon Publications.