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Geographical Mapping and Temporal Trends of Acinetobacter Baumannii Carbapenem Resistance: A Comprehensive Meta-Analysis Publisher Pubmed



Beig M1 ; Parvizi E2 ; Navidifar T3 ; Bostanghadiri N4 ; Mofid M5 ; Golab N6 ; Sholeh M1, 7
Authors
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Authors Affiliations
  1. 1. Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Department of Microbiology, Science and Research Branch, Islamic Azad University, Fars, Iran
  3. 3. Shoushtar Faculty of Medical Sciences, Department of Basic Sciences, Shoushtar, Iran
  4. 4. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. School of Medicine, Hamadan University of Medical Science, Hamadan, Iran
  6. 6. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, Pasteur Institute of Iran, Tehran, Iran

Source: PLoS ONE Published:2024


Abstract

Background Carbapenem-resistant Acinetobacter baumannii (CRAB) is of critical concern in healthcare settings, leading to limited treatment options. In this study, we conducted a comprehensive meta-analysis to assess the prevalence of CRAB by examining temporal, geographic, and bias-related variations. Methods We systematically searched prominent databases, including Scopus, PubMed, Web of Science, and EMBASE. Quality assessment was performed using the JBI checklist. Subgroup analyses were performed based on the COVID-19 timeframes, years, countries, continents, and bias levels, antimicrobial susceptivity test method and guidelines. Results Our comprehensive meta-analysis, which included 795 studies across 80 countries from 1995 to 2023, revealed a surge in carbapenem resistance among A. baumannii, imipenem (76.1%), meropenem (73.5%), doripenem (73.0%), ertapenem (83.7%), and carbapenems (74.3%). Temporally, 2020–2023 witnessed significant peaks, particularly in carbapenems (81.0%) and meropenem (80.7%), as confirmed by meta-regression, indicating a steady upward trend. Conclusion This meta-analysis revealed an alarmingly high resistance rate to CRAB as a global challenge, emphasizing the urgent need for tailored interventions. Transparency, standardized methodologies, and collaboration are crucial for the accurate assessment and maintenance of carbapenem efficacy. © 2024 Beig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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