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Hypotensive Effect of Cichorium Intybus Extract in Rats Publisher



Sedighi M1 ; Cheraghi M1 ; Faghihi M2 ; Rahimimadiseh M3 ; Kiani AA4 ; Dehghani M1 ; Rasoulian B5 ; Nazari A1, 5
Authors
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Authors Affiliations
  1. 1. Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran
  2. 2. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Razi Herbal Medicines Research Center, School of Allied Medical Sciences, Department of Hematology and Blood Transfusion, Lorestan University of Medical Science, Khorramabad, Iran
  5. 5. Razi Herbal Medicines Research Center, Department of Physiology, Lorestan University of Medical Science, Khorramabad, Iran

Source: Journal of HerbMed Pharmacology Published:2021


Abstract

Introduction: Oxidative stress is involved in many diseases, including hypertension, kidney failure, and heart disease. This study aimed to evaluate the effect of hydroalcoholic Cichorium intybus extract on blood pressure in rats. Antioxidant activity, phenolic and flavonoid contents of the plant extract were also evaluated. Methods: In this study, 32 male Wistar rats weighing 250-300 g were divided into four groups of eight each. Animals in the control group were administered with normal saline and in the C. intybus groups with extract at 25, 50, and 100 mg/kg for two weeks. Then, the homodynamic parameters were examined by the Power lab. The phenolic and flavonoid contents were also evaluated by a spectrophotometer and the rate of free radical scavenging activity was measured by the diphenyl-1-picyryl-hydrazyl (DPPH) free radical method. Results: The free radical scavenging activity of C. intybus extract was obtained 47.85% of DPPH, and flavonoid and phenolic contents were 8.21 and 27.19 mg/g of dry extract, respectively. Meanwhile, median (MAP), systolic (SAP) and diastolic arterial pressure (DAP) significantly decreased in the 50 mg/kg extract-treated group compared to the control and 200 mg/kg extract-treated groups. Conclusion: Ethanol extract of C. intybus plays a protective role against hypertension, which, in part, might be due to antioxidant compounds of the plant against free radicals. © 2021 Nickan Research Institute. All rights reserved.
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